1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-(4-chlorophenyl)piperidine-4-carboxamide CAS 337919-69-4
| CAS No. | 337919-69-4 |
| Molecular Formula | C18H16Cl2F3N3O |
| Molecular Weight | 418.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-(4-chlorophenyl)piperidine-4-carboxamide is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-(4-chlorophenyl)piperidine-4-carboxamide (CAS 337919-69-4), molecular formula C18H16Cl2F3N3O and molecular weight 418.24 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-(4-chlorophenyl)piperidine-4-carboxamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 418.24 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-(4-chlorophenyl)piperidine-4-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H16Cl2F3N3O |
| Molecular Weight | 418.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- (4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)piperazin-1-yl)(4-chlorophenyl)methanone (CAS 1311278-56-4)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-one O-(4-chlorobenzyl) oxime (CAS 250714-04-6)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1-(4-(3-chlorophenyl)piperazin-1-yl)ethan-1-one (CAS 691858-21-6)
- 2-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-(4-chlorophenyl)ethan-1-one (CAS 338979-09-2)
- (R)-4-chloro-6-(1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-2-amine (CAS 1675978-29-6)
- (3-(2-Chloro-6-fluorophenyl)-5-methylisoxazol-4-yl)(5-(chlorodifluoromethyl)-2,3-dihydro-1H-1,4-diazepin-1-yl)methanone (CAS 439096-47-6)
- 1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}-3-cyanopropan-2-yl 4-chlorobenzoate (CAS 338968-33-5)
- (E)-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methoxy}({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methylidene})amine (CAS 400081-12-1)
Recommended Standards
- N'-[(1E)-(4-Ethylphenyl)methylidene]-6-iodoimidazo[1,2-a]pyridine-2-carbohydrazide (CAS 939762-08-0)
- 6-Bromo-2-(3,4,5-trimethoxyphenyl)quinoline-4-carboxylic acid (CAS 351329-63-0)
- N-(1-(3,4-dichlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-nitrobenzamide (CAS 339009-14-2)
- 9-(2,5-Difluorophenyl)-2,4-bis(trifluoromethyl)-[1,2,4]triazolo[4,3-a][1,8]naphthyridine (CAS 338962-28-0)
- 22(S)-hydroxycholesterol-d7 (CAS 1246302-91-9)
- Dodecylcyclohexane (CAS 1795-17-1)
- tert-Butyl 3-(4-chlorophenyl)-5-oxo-2H-pyrrole-1-carboxylate (CAS 928215-97-8)
- (2S)-2-(4-bromophenoxy)propanoic acid (CAS 37819-43-5)
- 6-Chloro-2-(furan-2-yl)imidazo[1,2-a]pyridine (CAS 904818-13-9)
- 2-(4-(3,5-Di(1H-1,2,3-triazol-4-yl)phenyl)-1H-1,2,3-triazol-1-yl)acetic acid (CAS 958299-25-7)
- (R)-9-Hydroxy-2-(2-hydroxypropan-2-yl)-2,3-dihydro-7H-furo[3,2-g]chromen-7-one (CAS 68692-61-5)
- Ethyl 4,5-dimethyl-2-(2-((4-phenyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)acetamido)thiophene-3-carboxylate (CAS 332376-37-1)
- Ethyl 2-ethoxy-7-hydroxybenzo[d][1,3]dioxole-5-carboxylate (CAS 733746-42-4)
- Peptide Impurity 64 (CAS CATO-CPTD788964)
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