5-Chloro-1-(4-nitrobenzyl)-3-phenyl-2-(trifluoromethyl)-1H-indole CAS 337921-12-7
| CAS No. | 337921-12-7 |
| Molecular Formula | C22H14ClF3N2O2 |
| Molecular Weight | 430.81 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-Chloro-1-(4-nitrobenzyl)-3-phenyl-2-(trifluoromethyl)-1H-indole (C22H14ClF3N2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
5-Chloro-1-(4-nitrobenzyl)-3-phenyl-2-(trifluoromethyl)-1H-indole (CAS 337921-12-7) is a high-purity analytical reference standard with the molecular formula C22H14ClF3N2O2 and a molecular weight of 430.81 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Chloro-1-(4-nitrobenzyl)-3-phenyl-2-(trifluoromethyl)-1H-indole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H14ClF3N2O2 |
| Molecular Weight | 430.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
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Recommended Standards
- 5-(Benzyloxy)-1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indole-3-carbaldehyde (CAS 338409-98-6)
- N-(2-((4-bromophenyl)thio)ethyl)-2-((4-chlorophenyl)thio)propanamide (CAS 337923-63-4)
- N-((4-Chlorophenyl)carbamoyl)-2-(((6-nitro-4-oxoquinazolin-3(4H)-yl)methyl)amino)acetamide (CAS 76979-57-2)
- 2,4,6,8,10-Pentamethyl-2,4,6,8,10-pentavinyl-1,3,5,7,9,2,4,6,8,10-pentaoxapentasilecane (CAS 17704-22-2)
- (r)-2-Amino-2-(4-fluoro-3-(trifluoromethyl)phenyl)ethan-1-ol (CAS 1213208-99-1)
- N-methyl-6-oxo-6,6a,7,8,9,10-hexahydro-5H-pyrido[1,2-a]quinoxaline-3-sulfonamide (CAS 1105556-90-8)
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- TAPI 0 (CAS 163958-73-4)
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- Semaglutide Impurity 148 (CAS CATO-C4X-2226148)
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