1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-[2-(4-nitrophenoxy)ethyl]piperazine CAS 338409-52-2
| CAS No. | 338409-52-2 |
| Molecular Formula | C18H18ClF3N4O3 |
| Molecular Weight | 430.81 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-[2-(4-nitrophenoxy)ethyl]piperazine (C18H18ClF3N4O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-[2-(4-nitrophenoxy)ethyl]piperazine (CAS 338409-52-2), a certified reference material (molecular formula C18H18ClF3N4O3, MW 430.81 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-[2-(4-nitrophenoxy)ethyl]piperazine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H18ClF3N4O3 |
| Molecular Weight | 430.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- 5-Chloro-1-(4-nitrobenzyl)-3-phenyl-2-(trifluoromethyl)-1H-indole (CAS 337921-12-7)
- Ethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-{[(3-methoxyphenyl)methyl]carbamoyl}acetate (CAS 478063-74-0)
- 3-Chloro-2-(1-(phenylsulfonyl)-3-(1H-1,2,4-triazol-5-yl)propyl)-5-(trifluoromethyl)pyridine (CAS 338420-82-9)
- N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-((4-ethyl-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 618412-60-5)
- (S)-1-[4-[6-Chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-2-propen-1-one (CAS 1698055-85-4)
- 2-(2-(2-((6-Chloro-2-methoxyacridin-9-yl)amino)acetamido)acetamido)acetic acid (CAS 92515-32-7)
- 4-((4-(2-Chloro-4-nitrophenoxy)butyl)carbamoyl)benzene-1-sulfonyl fluoride (CAS 25313-34-2)
- 4-(5-(2-Chloro-4-nitrophenoxy)pentanamido)benzene-1-sulfonyl fluoride (CAS 30885-86-0)
Recommended Standards
- N-((4-Chlorophenyl)carbamoyl)-2-(((6-nitro-4-oxoquinazolin-3(4H)-yl)methyl)amino)acetamide (CAS 76979-57-2)
- 5-(Benzyloxy)-1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indole-3-carbaldehyde (CAS 338409-98-6)
- 1,2,4,5-Tetrakis(tert-butylthio)benzene (CAS 447463-65-2)
- 2,4-Dibromo-3-iodo-6-(trifluoromethyl)pyridine (CAS 1214348-26-1)
- n-(2-Cyanoethyl)-2-((4-hydroxyphenyl)thio)-N-methylacetamide (CAS 1178316-97-6)
- 2-(4-Methoxy-6-methylpyridin-2-yl)acetic acid (CAS 1393530-19-2)
- Methyl 4-(2-amino-4-fluorophenoxy)benzoate (CAS 946684-01-1)
- {4-[(2-methyl-1,3-thiazol-4-yl)methyl]piperidin-4-yl}methanol (CAS 1494635-48-1)
- tert-Butyl ((1,2,4-triazin-3-yl)methyl)carbamate (CAS 169902-07-2)
- Isoquinoline-7-carbothioamide (CAS 1337881-69-2)
- 2-(4-Chloro-2,6-dimethylphenoxy)acetic acid (CAS 39944-18-8)
- Ethyl 4-(4-chlorophenyl)-2-(furan-2-carboxamido)thiophene-3-carboxylate (CAS 6240-36-4)
- 4-Iodo-2,5-dimethylphenol (CAS 114971-53-8)
- Insulin Degludec Impurity 19 (CAS CATO-C4X-215719)
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