2-[3-(Trifluoromethyl)phenoxy]-3-[3-(trifluoromethyl)phenyl]quinoline CAS 337921-91-2
| CAS No. | 337921-91-2 |
| Molecular Formula | C23H13F6NO |
| Molecular Weight | 433.35 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 2-[3-(Trifluoromethyl)phenoxy]-3-[3-(trifluoromethyl)phenyl]quinoline (CAS 337921-91-2), a certified reference material (molecular formula C23H13F6NO, MW 433.35 g/mol) for analytical method development and quality control.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 2-[3-(Trifluoromethyl)phenoxy]-3-[3-(trifluoromethyl)phenyl]quinoline is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 433.35 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H13F6NO |
| Molecular Weight | 433.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 5,7-Bis(2-(trifluoromethyl)phenyl)quinolin-8-ol (CAS 648896-57-5)
- 8-{[8-(trifluoromethyl)-1H,2H,3H,3aH,4H,5H-pyrrolo[1,2-a]quinoxalin-5-yl]sulfonyl}quinoline (CAS 861207-21-8)
- 1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-hydroxy-6-(trifluoromethyl)pyrimidin-2-yl)guanidine (CAS 618092-26-5)
- 2-(2-(2-((3-(Trifluoromethyl)phenoxy)methyl)thiazol-4-yl)ethyl)isoindoline-1,3-dione (CAS 860785-69-9)
- 7-(Trifluoromethyl)-5-{[3-(trifluoromethyl)phenyl]methyl}-1H,3H,3aH,4H,5H-[1,3]thiazolo[3,4-a]quinoxalin-4-one (CAS 1024063-92-0)
- N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)quinazolin-4-amine (CAS 573678-04-3)
- (((Trifluoromethyl)sulfonyl)oxy)bis((1R,2S,3R,5R)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)borane (CAS 108266-89-3)
- 4-(3-(5-(3,5-Bis(trifluoromethyl)phenyl)furan-2-yl)acryloyl)benzonitrile (CAS 258353-29-6)
Recommended Standards
- (E)-N-(2-(3-(benzylthio)-6-methyl-1,2,4-triazin-5-yl)vinyl)-O-(2,6-dichlorobenzyl)hydroxylamine (CAS 400078-26-4)
- 3-(4-Allyl-5-(allylthio)-4H-1,2,4-triazol-3-yl)-1-(2,4-dichlorobenzyl)pyridin-2(1H)-one (CAS 477853-07-9)
- ((2R,3S,4R,5R)-3,4-Dihydroxy-5-(6-((4-hydroxy-3-methylbutyl)amino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate (CAS 31284-94-3)
- N-(4-Chlorobenzyl)-2-((6-((2-chlorobenzyl)amino)pyrimidin-4-yl)thio)acetamide (CAS 1251699-02-1)
- 5-Methoxy-2-methylene-5-oxopentanoic acid (CAS 93633-32-0)
- 2-(Methylthio)nicotinohydrazide (CAS 232926-33-9)
- 2-(Pyridin-2-yl)quinolin-4-ol (CAS 110802-13-6)
- 4-Methoxy-3-((perchlorophenoxy)methyl)benzaldehyde (CAS 329222-74-4)
- 2-(Cyclopropoxymethyl)isonicotinic acid (CAS 2289489-68-3)
- 2-(2,5-Dimethoxyphenyl)imidazo[1,2-a]pyrimidine-3-carbaldehyde (CAS 891765-41-6)
- Testosterone Impurity 52 (CAS CATO-C4X-243252)
- 17374-22-0 5,6-Dimethyl-4-phenyl-4H-1,3,4-thiadiazine-2-thiol MFCD02039511 (CAS 17374-22-0)
- 4-(Pyrrolidin-2-yl)piperidine oxalate (CAS 1177312-44-5)
- Semaglutide Impurity 144 (CAS 394210-59-4)
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