N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)quinazolin-4-amine CAS 573678-04-3
| CAS No. | 573678-04-3 |
| Molecular Formula | C21H12F6N4 |
| Molecular Weight | 434.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)quinazolin-4-amine (CAS 573678-04-3) is a high-purity analytical reference standard with the molecular formula C21H12F6N4 and a molecular weight of 434.34 g/mol.
The molecular framework of N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)quinazolin-4-amine (C21H12F6N4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H12F6N4 |
| Molecular Weight | 434.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related N Standards
- (((Trifluoromethyl)sulfonyl)oxy)bis((1R,2S,3R,5R)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)borane (CAS 108266-89-3)
- 8-{[8-(trifluoromethyl)-1H,2H,3H,3aH,4H,5H-pyrrolo[1,2-a]quinoxalin-5-yl]sulfonyl}quinoline (CAS 861207-21-8)
- 4-(3-(5-(3,5-Bis(trifluoromethyl)phenyl)furan-2-yl)acryloyl)benzonitrile (CAS 258353-29-6)
- 2-[3-(Trifluoromethyl)phenoxy]-3-[3-(trifluoromethyl)phenyl]quinoline (CAS 337921-91-2)
- 5,7-Bis(2-(trifluoromethyl)phenyl)quinolin-8-ol (CAS 648896-57-5)
- 1-{[3,5-bis(trifluoromethyl)phenyl]methyl}-N-[2-(dimethylamino)ethyl]-2-oxo-1,2-dihydropyridine-3-carboxamide (CAS 338782-07-3)
- 3-(Trifluoromethyl)phenyl 2-(N-phenylbenzenesulfonamido)acetate (CAS 343373-54-6)
- 3-{benzyl[3-(trifluoromethyl)phenyl]sulfamoyl}benzoic acid (CAS 519152-26-2)
Recommended Standards
- Dichloro[N-(1,1-dimethylethyl)-1,1-dimethyl-1-[(1,2,3,3a,8a-η)-1,5,6,7-tetrahydro-2-methyl-s-indacen-1-yl]silanaminato(2-)-κN]titanium (CAS 202756-29-4)
- (2-Bromophenyl)(3-(phenylsulfonyl)-8-azabicyclo[3.2.1]octan-8-yl)methanone (CAS 1704515-62-7)
- 4-(4-Chlorophenyl)-6-[(4-chlorophenyl)sulfanyl]-2-phenylpyrimidine-5-carbonitrile (CAS 320418-49-3)
- 3-(((3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one (CAS 72581-58-9)
- 2-(1-Methyl-1H-pyrazol-5-yl)tetrahydrofuran-3-amine (CAS 1803565-76-5)
- 4-Methyl-1-[4-(propan-2-yl)phenyl]-2-sulfanyl-4,5-dihydro-1h-imidazol-5-one (CAS 1008283-53-1)
- Methyl 3-amino-6-(trifluoromethyl)benzo[b]thiophene-2-carboxylate (CAS 35212-91-0)
- 2,3-Diazabicyclo[2.2.1]heptane (CAS 279-31-2)
- (1-Phenyl-ethyl)thiourea (CAS 67398-34-9)
- 3-[(2-methoxyphenyl)methoxy]-2-methylaniline (CAS 1282185-33-4)
- 2-[(4-methylpiperazin-1-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazine (CAS 1016851-60-7)
- 5-Chloro-4-(trifluoromethyl)picolinamide (CAS 1805633-53-7)
- 3-(5-(Tetrahydro-2h-pyran-4-yl)-4h-1,2,4-triazol-3-yl)propan-1-amine (CAS 1481660-99-4)
- Liraglutide Impurity 31 (CAS CATO-C4X-199231)
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