1-[(5-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}thiophen-2-yl)sulfonyl]-4-(4-fluorophenyl)piperazine CAS 337924-67-1
| CAS No. | 337924-67-1 |
| Molecular Formula | C21H18ClF4N3O2S2 |
| Molecular Weight | 519.96 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-[(5-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}thiophen-2-yl)sulfonyl]-4-(4-fluorophenyl)piperazine is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-[(5-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}thiophen-2-yl)sulfonyl]-4-(4-fluorophenyl)piperazine (CAS 337924-67-1) is a high-purity analytical reference standard with the molecular formula C21H18ClF4N3O2S2 and a molecular weight of 519.96 g/mol.
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 1-[(5-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}thiophen-2-yl)sulfonyl]-4-(4-fluorophenyl)piperazine is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 519.96 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H18ClF4N3O2S2 |
| Molecular Weight | 519.96 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related chloro Standards
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- 2-Chloro-2-phenyl-1-(pyrrolidin-1-yl)ethan-1-one (CAS 190964-87-5)
- 2-Phenylmalonamide (CAS 10255-95-5)
- 3-Ethyl-3-methylpentan-2-ol (CAS 66576-22-5)
- 4-Fluoro-2-methylbenzeneboronic acid pinacol ester, 97% (CAS 815631-56-2)
- N-(2-chlorophenyl)-3-methylbenzamide (CAS 77791-08-3)
- 2-Acetamido-N1-benzyl-N3-(4-isopropylphenyl)malonamide (CAS 866039-22-7)
- (S)-4-Bromo-N-(2-hydroxypropyl)benzamide (CAS 1568209-41-5)
- 3-(4-Methoxyphenyl)quinoline (CAS 57479-32-0)
- Semaglutide Impurity 18 (CAS 1671100-14-3)
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