N4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-methylisoxazole-3,4-dicarboxamide CAS 338397-36-7
| CAS No. | 338397-36-7 |
| Molecular Formula | C12H8ClF3N4O3 |
| Molecular Weight | 348.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO supplies N4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-methylisoxazole-3,4-dicarboxamide (CAS 338397-36-7), a certified reference material (molecular formula C12H8ClF3N4O3, MW 348.67 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, N4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-methylisoxazole-3,4-dicarboxamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 348.67 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), N4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-methylisoxazole-3,4-dicarboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8ClF3N4O3 |
| Molecular Weight | 348.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related N Standards
- 3-Chloro-5-(trifluoromethyl)-2-((3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl)thio)pyridine (CAS 1823182-70-2)
- 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N'-(6-fluoropyridin-2-yl)acetohydrazide (CAS 691873-25-3)
- Methyl 2-chloro-5-(2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)benzoate (CAS 855316-20-0)
- 7-Chloro-5-phenyl-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinazoline (CAS 57370-31-7)
- 8-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1,3,8-triazaspiro[4.5]Decane-2,4-dione (CAS 338408-74-5)
- 2-(8-Chloro-3-(methoxymethoxy)naphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2621938-40-5)
- N-(3-Chloro-2-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine (Dacomitinib Impurity) (CAS 1454307-45-9)
- 2-[4-(4-Chloro-2-fluorophenoxy)phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (CAS 1426337-41-8)
Recommended Standards
- Regorafenib Impurity N2 (CAS 1333390-56-9)
- 4-(Chlorodifluoromethyl)-2-hydroxy-6-[4-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (CAS 439097-28-6)
- 1-(Boc-amino)-3-bromo-1-(3-chlorophenyl)propane (CAS 924817-77-6)
- 3-(4-Chlorophenyl)-5-((phenylselanyl)methyl)isoxazole (CAS 833462-33-2)
- n-(3-Chloro-4-methylphenyl)-4-methylpiperazine-1-carboxamide (CAS 853319-19-4)
- Chlorobenzilate (CAS 510-15-6)
- Di-tert-butyl (3-bromo-6-chloropyrazin-2-yl)iminodicarbonate (CAS 1801693-41-3)
- 2,2,4-Tris(2-chlorophenyl)-5-(3,4-dimethoxyphenyl)-4,5-diphenyl-1,1-biimidazole (CAS 100486-97-3)
- N,N-Dipropylbispidine (CAS 909037-18-9)
- Methyl 2-aminopentanoate hydrochloride (CAS 10047-10-6)
- Benzyl pent-4-ynoate (CAS 126378-11-8)
- 2-(3,4-Dimethylbenzoyl)pyridine (CAS 102001-19-4)
- 1-Bromo-2-fluoro-3-methoxy-5-(trifluoromethyl)benzene (CAS 2091605-16-0)
- Tau Peptide (301-315) trifluoroacetate salt (CAS 330456-48-9)
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