Regorafenib Impurity N2 CAS 1333390-56-9
| CAS No. | 1333390-56-9 |
| Molecular Formula | C14H9ClF4N2O2 |
| Molecular Weight | 348.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Regorafenib Impurity N2 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 348.68 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Regorafenib Impurity N2 (CAS 1333390-56-9), a pharmacopoeial impurity reference standard (molecular formula C14H9ClF4N2O2, MW 348.68 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Regorafenib Impurity N2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H9ClF4N2O2 |
| Molecular Weight | 348.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Regorafenib Standards
- Regorafenib Impurity 18 (CAS CATO-C4X-104718)
- Regorafenib Impurity 37 (CAS CATO-C4X-104737)
- Regorafenib Impurity 45 (CAS CATO-C4X-104745)
- Regorafenib Impurity 82 (CAS CATO-C4X-104782)
- Regorafenib Impurity 81 (CAS CATO-C4X-104781)
- Regorafenib Impurity 83 (CAS CATO-C4X-104783)
- Regorafenib Impurity 23 (CAS CATO-C4X-104723)
- Regorafenib Impurity 19 (CAS 2098799-12-1)
Recommended Standards
- N4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-methylisoxazole-3,4-dicarboxamide (CAS 338397-36-7)
- 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N'-(6-fluoropyridin-2-yl)acetohydrazide (CAS 691873-25-3)
- Methyl 2-chloro-5-(2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)benzoate (CAS 855316-20-0)
- 3-(4-Chlorophenyl)-5-((phenylselanyl)methyl)isoxazole (CAS 833462-33-2)
- Ilaprazole Impurity 121 (CAS 13436-43-6)
- Ertapenem Impurity 31 (CAS CATO-C4X-163331)
- Tenofovir alafenamide impurity 75 (CAS 379270-36-7)
- (4S)-4-(4-Trifluoromethyl-benzyl)-L-glutamic acid (CAS 207508-60-9)
- endo-norbornan-2-amine (CAS 31002-73-0)
- 2-((3-Cyano-6-methylpyridin-2-yl)thio)acetic acid (CAS 309279-80-9)
- 2-Chloro-N-[3-(diethylsulfamoyl)-4-methylphenyl]acetamide (CAS 379255-39-7)
- 6-Chloro-3-(methylamino)quinazolin-4(3H)-one (CAS 60512-87-0)
- 2-(3-Chlorophenyl)isoindolin-1-imine (CAS 321686-44-6)
- Nonapeptide-1 (CAS 158563-45-2)
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