(4E)-4-[(Dimethylamino)methylidene]-1-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one CAS 338403-22-8
| CAS No. | 338403-22-8 |
| Molecular Formula | C14H11F6N3O2 |
| Molecular Weight | 367.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (4E)-4-[(Dimethylamino)methylidene]-1-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(4E)-4-[(Dimethylamino)methylidene]-1-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one (CAS 338403-22-8), molecular formula C14H11F6N3O2 and molecular weight 367.25 g/mol, is a CATO reference standard with documented purity and traceability.
(4E)-4-[(Dimethylamino)methylidene]-1-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one (C14H11F6N3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures (4E)-4-[(Dimethylamino)methylidene]-1-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H11F6N3O2 |
| Molecular Weight | 367.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related E Standards
- N-[3-(2-Dimethylamino-5-trifluoromethyl-pyridin-3-yl)-phenyl]-2-ethoxy-acetamide (CAS 1311278-24-6)
- {[4-(6-Dimethylamino-4-trifluoromethyl-pyridin-2-yl)-benzyl]-methyl-amino}-acetic acid (CAS 1311278-83-7)
- N-(3-(6-(dimethylamino)-4-(trifluoromethyl)pyridin-2-yl)benzyl)-N-methylglycine (CAS 1311279-02-3)
- N-(4-(2-(dimethylamino)-5-(trifluoromethyl)pyridin-3-yl)benzyl)-N-methylglycine (CAS 1311279-35-2)
- {[3-(2-Dimethylamino-5-trifluoromethyl-pyridin-3-yl)-benzyl]-methyl-amino}-acetic acid (CAS 1311279-74-9)
- N-(2-(dimethylamino)ethyl)-2-oxo-1-(3-(trifluoromethyl)benzyl)-1,2-dihydropyridine-3-carboxamide (CAS 338754-92-0)
- N-{1-({2-[(Dimethylamino)methylene]hydrazino}carbonyl)-2-[(4-methyl-2-pyrimidinyl)amino]vinyl}benzenecarboxamide (CAS 339010-35-4)
- {3-[(Dimethylamino)sulfonyl]-6-oxo-6,6a,7,8,9,10-hexahydro-5H-pyrido[1,2-a]quinoxalin-5-yl}acetic acid (CAS 1101836-50-3)
Recommended Standards
- N-Benzyl-2-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide (CAS 1706749-35-0)
- (5E)-3-(4-Chlorophenyl)-5-{[(4-chlorophenyl)amino]methylidene}-4-oxo-1,3-thiazolidin-1-ium-1-olate (CAS 338752-82-2)
- 2,7-Dichloro-4-methyl-N-phenylquinoline-6-sulfonamide (CAS 1418265-69-6)
- (R)-N-[2-(4-Iodophenyl)propyl]propane-2-sulfonamide (CAS 375345-98-5)
- 5-Nitro-2-(piperidin-3-yloxy)pyridine hydrochloride (CAS 1185312-46-2)
- 5-chloro-2H-[1,2,3]triazolo[4,5-d]pyrimidine (CAS 2634677-10-2)
- Ethyl 1-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate (CAS 339102-32-8)
- 2-Methoxypentanoic acid (CAS 54623-61-9)
- Salmeterol EP Impurity F (CAS 1391054-40-2)
- Isavuconazole Impurity N12 (CAS 2732924-98-8)
- 4-Chlorophenylacetyl chloride (CAS 25026-34-0)
- (3-Bromopropyl)cyclohexane (CAS 34094-21-8)
- 3-(((1-Isopropylcyclopropyl)methyl)amino)thietane 1,1-dioxide (CAS 1870454-65-1)
- Semaglutide impurity 256 (CAS CATO-C4X-2226256)
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