6-(4-Fluorophenyl)-2-(4-phenylpiperazin-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine CAS 338403-76-2
| CAS No. | 338403-76-2 |
| Molecular Formula | C21H20FN7 |
| Molecular Weight | 389.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 6-(4-Fluorophenyl)-2-(4-phenylpiperazin-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
6-(4-Fluorophenyl)-2-(4-phenylpiperazin-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine (CAS 338403-76-2), molecular formula C21H20FN7 and molecular weight 389.43 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 6-(4-Fluorophenyl)-2-(4-phenylpiperazin-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine (C21H20FN7) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 389.43 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-(4-Fluorophenyl)-2-(4-phenylpiperazin-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H20FN7 |
| Molecular Weight | 389.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 7 |
Related Fluorophenyl Standards
- Ethyl (2-((3-(3-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)acetyl)glycinate (CAS 852374-92-6)
- 2-(4-(2-Fluorophenyl)piperazin-1-yl)-N,N-diphenylacetamide (CAS 1024400-18-7)
- 2-(4-(2-Fluorophenyl)piperazin-1-yl)-N-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)acetamide (CAS 227957-81-5)
- 2-[4-(4-Fluorophenyl)piperazin-1-yl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide (CAS 478045-29-3)
- 3-(4-Fluorophenyl)-6-(4-(trifluoromethyl)benzyl)-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one (CAS 892480-74-9)
- 4-[(1Z)-[(4-Fluorophenyl)imino]methyl]phenyl 4-chlorobenzene-1-sulfonate (CAS 331460-70-9)
- 1-(4-Fluorophenyl)-9-methyl-2-(2,3,4-trifluorophenoxy)-1H-purin-6(9H)-one (CAS 1009032-45-4)
- 2-(4-Fluorophenyl)-3,5-dioxo-4-(4-(trifluoromethyl)benzyl)-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile (CAS 477845-35-5)
Recommended Standards
- 4-[4-(Pyridin-2-yl)pyrimidin-2-yl]phenyl benzenesulfonate (CAS 477857-50-4)
- Cefprozil (CAS 92665-29-7)
- 2-(4-(Furan-2-carbonyl)piperazin-1-yl)-2-oxoethyl 2-(methylthio)nicotinate (CAS 380452-13-1)
- Methyl 3-[4-([1,1-biphenyl]-4-ylcarbonyl)-1H-1,2,3-triazol-1-yl]-2-thiophenecarboxylate (CAS 439111-70-3)
- Methyl 5-(((4-chlorophenyl)sulfonyl)methyl)furan-2-carboxylate (CAS 886498-59-5)
- Methyl 5-((2-nitrophenoxy)methyl)furan-2-carboxylate (CAS 375356-39-1)
- 4-(Benzyloxy)-N-methyl-2-nitroaniline (CAS 1951439-76-1)
- 2-(4-Methyl-4H-1,2,4-triazol-3-yl)ethan-1-ol (CAS 1517255-85-4)
- 5,5-Dimethyl-3-[(5-methylisoxazol-3-yl)amino]-cyclohex-2-en-1-one (CAS 897660-79-6)
- (4-Bromo-3-fluorophenyl)(3-methoxyphenyl)methanone (CAS 750633-75-1)
- Propan-2-yl 5-bromo-2-fluorobenzoate (CAS 1369403-80-4)
- (4-(4-(Methoxycarbonyl)phenoxy)-3-nitrophenyl)methylene diacetate (CAS 886361-08-6)
- Ethyl 2-(2-aminobenzoyl)hydrazinecarboxylate (CAS 30481-61-9)
- Semaglutide impurity 201 (CAS CATO-C4X-2226201)
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