4-Chloro-N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)benzamide CAS 338409-32-8
| CAS No. | 338409-32-8 |
| Molecular Formula | C15H12Cl2F3N3O |
| Molecular Weight | 378.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)benzamide.
4-Chloro-N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)benzamide (CAS 338409-32-8) is a high-purity analytical reference standard with the molecular formula C15H12Cl2F3N3O and a molecular weight of 378.18 g/mol.
The molecular framework of 4-Chloro-N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)benzamide (C15H12Cl2F3N3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)benzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H12Cl2F3N3O |
| Molecular Weight | 378.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 3-Chloro-6-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}pyridazine (CAS 303149-98-6)
- (2E)-3-[3-Chloro-2-sulfanylidene-5-(trifluoromethyl)-1,2-dihydropyridin-1-yl]-1-(4-chlorophenyl)prop-2-en-1-one (CAS 338953-40-5)
- (2Z)-3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}-1-(4-chlorophenyl)prop-2-en-1-one (CAS 288270-43-9)
- 2-Chloro-N-[6-chloro-3-(3-methoxyphenyl)-4-oxo-4H-chromen-2-yl]acetamide (CAS 1017420-48-2)
- 3-(2-Chloro-6-fluorobenzyl)-1-(3-chlorobenzyl)-4-hydroxypyridin-2(1H)-one (CAS 477869-76-4)
- 6-chloro-N'-(3-chlorobenzoyl)-4-(trifluoromethyl)nicotinohydrazide (CAS 287979-15-1)
- 2-Chloro-3-(4-chlorobenzenesulfonyl)-4-methyl-6-phenylpyridine (CAS 343372-75-8)
- N-(3-chloro-4-methylphenyl)-2-(4-(3-chlorophenyl)piperazin-1-yl)acetamide (CAS 477333-99-6)
Recommended Standards
- Posaconazole Impurity 131 (CAS CATO-C4X-1208131)
- tert-Butyl 3-(bromomethyl)-5-(trifluoromethyl)-1H-indole-1-carboxylate (CAS 1823499-57-5)
- (2E)-3-(6-Bromo-2H-1,3-benzodioxol-5-yl)-N-[(4-fluorophenyl)methyl]prop-2-enamide (CAS 1164529-57-0)
- 3-((Tributylstannyl)methoxy)propan-1-amine (CAS 1577233-70-5)
- 3,5-Dicarboxy-1-methylpyridin-1-ium iodide (CAS 84824-91-9)
- tert-Butyl 3-(((2-bromobenzyl)amino)methyl)pyrrolidine-1-carboxylate (CAS 887590-78-5)
- 3-(2-Fluorophenyl)-6-methyl-2-(methylthio)pyrimidin-4(3H)-one (CAS 89089-61-2)
- Naltrexone Impurity 29 (CAS CATO-C4X-147529)
- Ethyl 5-amino-5,6-dihydro-4H-cyclopenta[c]furan-5-carboxylate (CAS 266350-29-2)
- Tert-butyl (2S,4R)-4-amino-2-(hydroxymethyl)pyrrolidine-1-carboxylate hydrochloride (CAS 1279038-32-2)
- 1-(2-Aminobenzo[d]oxazol-4-yl)ethanone (CAS 1807067-17-9)
- 2-(1-chloroethyl)-5-methyl-1,3,4-thiadiazole (CAS 1461715-44-5)
- [1-(difluoromethyl)pyrazol-4-yl]methanol (CAS 2098020-65-4)
- Renin Inhibitor Peptide (CAS 50410-01-0)
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