2-((1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indol-3-yl)methylene)malononitrile CAS 338409-96-4
| CAS No. | 338409-96-4 |
| Molecular Formula | C18H8ClF3N4 |
| Molecular Weight | 372.73 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-((1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indol-3-yl)methylene)malononitrile.
CATO supplies 2-((1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indol-3-yl)methylene)malononitrile (CAS 338409-96-4), a certified reference material (molecular formula C18H8ClF3N4, MW 372.73 g/mol) for analytical method development and quality control.
Structurally, 2-((1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indol-3-yl)methylene)malononitrile (C18H8ClF3N4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 372.73 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-((1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indol-3-yl)methylene)malononitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H8ClF3N4 |
| Molecular Weight | 372.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- N-[[(5-Chloro-2-Hydroxyphenyl)-Phenylmethyl]Carbamoyl]-2,2,2-Trifluoroacetamide (CAS 160776-86-3)
- (Z)-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]({[(pyridin-3-yl)methyl]amino})methylidene}amino acetate (CAS 320420-59-5)
- 2-{[2-Chloro-5-(trifluoromethyl)phenyl]amino}-2-oxoethyl 4-aminobenzoate (CAS 931259-26-6)
- 4-[5-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}methyl)-4,5-dihydro-1,2-oxazol-3-yl]pyrimidin-2-amine (CAS 344277-07-2)
- 4-((4-Chloro-3-nitrophenyl)sulfonamido)-2-hydroxybenzoic acid (CAS 328028-09-7)
- 5-(2-Chloro-4-(trifluoromethyl)phenoxy)-3-ethoxyisobenzofuran-1(3H)-one (CAS 99199-19-6)
- 5-(2-Chloro-5-nitrobenzenesulfonamido)-2-hydroxybenzoic acid (CAS 328028-30-4)
- 5-(4-Chloro-3-nitro-benzenesulfonylamino)-2-hydroxy-benzoic acid (CAS 325732-20-5)
Recommended Standards
- 2-(4-Chlorophenoxy)-N'-[(1E)-[4-(trifluoromethoxy)phenyl]methylidene]acetohydrazide (CAS 868630-56-2)
- 7-Chloro-5-[(3,4-dichlorophenyl)methyl]-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one (CAS 341968-14-7)
- N-(benzo[d][1,3]dioxol-5-ylmethyl)-2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)acetamide (CAS 478063-69-3)
- 7-Chloro-5-[(2,6-dichlorophenyl)methyl]-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one (CAS 303987-48-6)
- 3-Cyclopropylpyridazine (CAS 63359-57-9)
- 4-(1,4,6,7-Tetrahydropyrano[4,3-c]pyrazol-3-yl)aniline (CAS 2138570-31-5)
- 3-Mercaptolactic Acid (CAS 2614-83-7)
- Methyl 5-ethyl-3-hydroxythiophene-2-carboxylate (CAS 181312-88-9)
- (2R,3R,4R,5R)-5-(2-Amino-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol (CAS 134444-48-7)
- 1-(4-Chlorophenyl)hexan-1-amine hydrochloride (CAS 5461-40-5)
- 4-Bromo-2,5-bis((2-ethylhexyl)oxy)benzaldehyde (CAS 945624-63-5)
- ethyl 3-hydroxy-5-methyl-pyrazine-2-carboxylate (CAS 141872-22-2)
- 2-Carboxythiophene-5-boronic acid (CAS 465515-31-5)
- Semaglutide impurity 36 (CAS CATO-C4X-222636)
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