2-Hydroxy-2-methyl-3-(4-methylbenzenesulfonyl)-N-[3-(trifluoromethyl)phenyl]propanamide CAS 338424-47-8
| CAS No. | 338424-47-8 |
| Molecular Formula | C18H18F3NO4S |
| Molecular Weight | 401.40 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Hydroxy-2-methyl-3-(4-methylbenzenesulfonyl)-N-[3-(trifluoromethyl)phenyl]propanamide is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 2-Hydroxy-2-methyl-3-(4-methylbenzenesulfonyl)-N-[3-(trifluoromethyl)phenyl]propanamide (CAS 338424-47-8), a certified reference material (molecular formula C18H18F3NO4S, MW 401.40 g/mol) for analytical method development and quality control.
The molecular framework of 2-Hydroxy-2-methyl-3-(4-methylbenzenesulfonyl)-N-[3-(trifluoromethyl)phenyl]propanamide (C18H18F3NO4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Hydroxy-2-methyl-3-(4-methylbenzenesulfonyl)-N-[3-(trifluoromethyl)phenyl]propanamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H18F3NO4S |
| Molecular Weight | 401.40 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Hydroxy Standards
- 2-Hydroxy-2-methyl-3-phenylmethanesulfonyl-N-[3-(trifluoromethyl)phenyl]propanamide (CAS 339275-66-0)
- 2-Hydroxy-2-methyl-3-phenylmethanesulfonyl-N-[4-(trifluoromethyl)phenyl]propanamide (CAS 338956-15-3)
- (2-(3-Hydroxy-4-(2-phenoxyacetyl)phenoxy)acetyl)-L-valine (CAS 956752-63-9)
- N-(2-(2-hydroxy-3-methoxynaphthalen-1-yl)-4-methoxy-3,5-dimethylphenyl)methanesulfonamide (CAS 1832514-13-2)
- N-(2-(2-hydroxy-7-methoxynaphthalen-1-yl)-4-methoxy-3,5-dimethylphenyl)methanesulfonamide (CAS 1832514-16-5)
- 1-(5-(2-Hydroxy-3-methoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-2-morpholinoethan-1-one (CAS 877972-14-0)
- 1-(5-(3-Hydroxy-4-methoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-2-morpholinoethan-1-one (CAS 900013-22-1)
- 6-Hydroxy Buspirone (CAS 125481-61-0)
Recommended Standards
- 2-{[3-amino-6-ethyl-4-(trifluoromethyl)-5H,6H,7H,8H-thieno[2,3-b]quinolin-2-yl]formamido}acetic acid (CAS 939893-70-6)
- 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(3,3-difluorocyclopentyl)acetic acid (CAS 2138774-35-1)
- 1-Methyl-3-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide (CAS 478066-99-8)
- Acalisib, >98% (HPLC) (CAS 870281-34-8)
- 9-Hydroxymethyl-10-hydroxy Camptothecin (CAS 175613-38-4)
- 1-Methoxyphthalazine (CAS 24953-56-8)
- 3-(2-Methyl-5-(trifluoromethyl)phenyl)propanoic acid (CAS 1017778-12-9)
- 4-Cyclopropoxy-N-methyl-2-(methylthio)nicotinamide (CAS 1243480-22-9)
- (5-Amino-1-phenyl-1H-pyrazol-4-yl)(2-chlorophenyl)methanone (CAS 190269-18-2)
- Tetramethylammonium Methyl Carbonate (CAS 22426-79-5)
- 2-(4-AMINOPHENYL)-3-(4-BROMOPHENYL)PROPANOIC ACID (CAS 1547131-56-5)
- Methyl cis-2-(Boc-amino)cyclopentanecarboxylate (CAS 164916-42-1)
- 2-(7,8-Dihydroxy-2-oxo-2H-chromen-4-yl)acetic acid (CAS 19040-72-3)
- Tirzepatide Impurity 43 (CAS CATO-C4X-324043)
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