2-Hydroxy-2-methyl-3-phenylmethanesulfonyl-N-[3-(trifluoromethyl)phenyl]propanamide CAS 339275-66-0
| CAS No. | 339275-66-0 |
| Molecular Formula | C18H18F3NO4S |
| Molecular Weight | 401.40 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 2-Hydroxy-2-methyl-3-phenylmethanesulfonyl-N-[3-(trifluoromethyl)phenyl]propanamide (CAS 339275-66-0), a certified reference material (molecular formula C18H18F3NO4S, MW 401.40 g/mol) for analytical method development and quality control.
The molecular framework of 2-Hydroxy-2-methyl-3-phenylmethanesulfonyl-N-[3-(trifluoromethyl)phenyl]propanamide (C18H18F3NO4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-Hydroxy-2-methyl-3-phenylmethanesulfonyl-N-[3-(trifluoromethyl)phenyl]propanamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H18F3NO4S |
| Molecular Weight | 401.40 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Hydroxy Standards
- 2-Hydroxy-2-methyl-3-(4-methylbenzenesulfonyl)-N-[3-(trifluoromethyl)phenyl]propanamide (CAS 338424-47-8)
- 2-Hydroxy-2-methyl-3-phenylmethanesulfonyl-N-[4-(trifluoromethyl)phenyl]propanamide (CAS 338956-15-3)
- (2-(3-Hydroxy-4-(2-phenoxyacetyl)phenoxy)acetyl)-L-valine (CAS 956752-63-9)
- N-(2-(2-hydroxy-3-methoxynaphthalen-1-yl)-4-methoxy-3,5-dimethylphenyl)methanesulfonamide (CAS 1832514-13-2)
- N-(2-(2-hydroxy-7-methoxynaphthalen-1-yl)-4-methoxy-3,5-dimethylphenyl)methanesulfonamide (CAS 1832514-16-5)
- 1-(5-(2-Hydroxy-3-methoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-2-morpholinoethan-1-one (CAS 877972-14-0)
- 1-(5-(3-Hydroxy-4-methoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-2-morpholinoethan-1-one (CAS 900013-22-1)
- 6-Hydroxy Buspirone (CAS 125481-61-0)
Recommended Standards
- 2-{[3-amino-6-ethyl-4-(trifluoromethyl)-5H,6H,7H,8H-thieno[2,3-b]quinolin-2-yl]formamido}acetic acid (CAS 939893-70-6)
- Acalisib, >98% (HPLC) (CAS 870281-34-8)
- 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(3,3-difluorocyclopentyl)acetic acid (CAS 2138774-35-1)
- Ethyl 2-piperazin-1-yl-4-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxylate (CAS 887267-70-1)
- (R)-4-(((9h-Fluoren-9-yl)methoxy)carbonyl)piperazine-2-carboxylic acid (CAS 747393-31-3)
- (S)-3-(2-Bromo-4-methoxyphenyl)-2-(4-methoxyphenyl)propan-1-ol (|AS)-2-Bromo-4-methoxy-|A-(4-methoxyphenyl)benzenepropanol 917379-11-4 (CAS 917379-11-4)
- α,4-Di-O-acetyl Vanillylmandelic Acid Ethyl Ester (CAS 1329795-85-8)
- Benzyl (S)-4-(trifluoromethyl)-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide (CAS 2920746-96-7)
- 2,3,4-Trimethoxy-N-(2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide (CAS 103595-49-9)
- Milrinone impurity 43 (CAS CATO-C4X-109143)
- D-Arg8-Cetrorelix (CAS CATO-C4X-201427)
- 2-(4-(2-((2-(Trimethylsilyl)ethoxy)methyl)-2H-tetrazol-5-yl)phenyl)ethan-1-ol (CAS 1313712-16-1)
- 5,7-Difluoro-2,3-dihydro-1H-inden-1-amine (CAS 173998-72-6)
- Peptide Impurity 09 X TFA Salt (CAS CATO-CPTD788809)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com