Ethyl 5-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate CAS 33851-24-0
| CAS No. | 33851-24-0 |
| Molecular Formula | C11H9ClO3S |
| Molecular Weight | 256.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ethyl 5-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate is closely related to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Ethyl 5-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate (CAS 33851-24-0), molecular formula C11H9ClO3S and molecular weight 256.71 g/mol, is a CATO reference standard with documented purity and traceability.
Ethyl 5-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate (C11H9ClO3S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Ethyl 5-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H9ClO3S |
| Molecular Weight | 256.71 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
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Recommended Standards
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- N-(4-(bis(4-(dimethylamino)phenyl)methylene)cyclohexa-2,5-dien-1-ylidene)-N-methylmethanaminium (CAS 7438-46-2)
- 1-ethyl-3-(thiophen-2-yl)-4,5,6,7-tetrahydro-1h-pyrazolo[4,3-c]pyridine (CAS 87642-40-8)
- N-{2-[4-(Methylsulfonyl)piperazino]phenyl}-2-thiophenecarboxamide (CAS 478260-33-2)
- Ethyl 2-chloro-3-fluoro-5-pyridinecarboxylate (CAS 1214332-76-9)
- Tert-butyl (4aR,8aR)-octahydro-1H-pyrido[3,4-b][1,4]oxazine-1-carboxylate (CAS 1616434-40-2)
- (Gly1,Ser3·22,Gln?·3?,Thr?,Arg1?,Tyr21,Ala23·31,Aib32)-Pancreatic Polypeptide (human) (CAS 313988-89-5)
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