1-Bromo-3-chloro-5-fluorobenzene CAS 33863-76-2
| CAS No. | 33863-76-2 |
| Molecular Formula | C6H3BrClF |
| Molecular Weight | 209.44 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-Bromo-3-chloro-5-fluorobenzene (CAS 33863-76-2) is a high-purity analytical reference standard with the molecular formula C6H3BrClF and a molecular weight of 209.44 g/mol.
Owing to fluorine/chlorine/bromine substitution, an aromatic ring system, 1-Bromo-3-chloro-5-fluorobenzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 209.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 1-Bromo-3-chloro-5-fluorobenzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H3BrClF |
| Molecular Weight | 209.44 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | F/Cl/Br-containing |
Related Bromo Standards
- 1-Bromo-2-chloro-4-fluorobenzene (CAS 110407-59-5)
- 1-Bromo-3-chloro-2-fluorobenzene (CAS 144584-65-6)
- 1-Bromo-2-chloro-3-fluorobenzene (CAS 883499-24-9)
- 1-Bromo-4-chloro-2-fluorobenzene (CAS 1996-29-8)
- 2-Bromo-1-chloro-3-fluorobenzene (CAS 309721-44-6)
- 2-Bromo-1-chloro-4-fluorobenzene (CAS 201849-15-2)
- 2-Bromo-4-chloro-1-fluorobenzene (CAS 1996-30-1)
- 4-Bromo-1-chloro-2-fluorobenzene (CAS 60811-18-9)
Recommended Standards
- (6-Chloro-1-methyl-1H-indol-2-yl)boronic acid (CAS 957066-11-4)
- Palbociclib Impurity 118 (CAS 844843-37-4)
- 5-Bromo-6-chloro-4-pyrimidone (CAS 89089-19-0)
- 4-Bromo-2-chloro-1-fluorobenzene (CAS 60811-21-4)
- (R)-2-acetamidohexanoic acid (CAS 54896-21-8)
- tert-Butyl 1-azaspiro[2.4]heptane-1-carboxylate (CAS 1956376-92-3)
- 2,3,4,5,6-Pentahydroxyhexanal (CAS 93780-23-5)
- Methyl 4-(fluoromethyl)benzoate (CAS 64299-49-6)
- Methyl 8-iodoisoquinoline-3-carboxylate (CAS 1982328-50-6)
- 5-(tert-Butyl)-2-hydroxypyridine (CAS 1159819-76-7)
- Suzetrigine Impurity 24 (CAS 3083330-03-1)
- 2-Methylpropane-1,2,3-tricarboxylic acid (CAS 1590-02-9)
- 4-(4-Chloro-benzyloxy)-benzaldehyde (CAS 59067-46-8)
- Semaglutide impurity 229 (CAS CATO-C4X-2226229)
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