Palbociclib Impurity 118 CAS 844843-37-4
| CAS No. | 844843-37-4 |
| Molecular Formula | C4H2BrClN2O |
| Molecular Weight | 209.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Palbociclib Impurity 118.
As a process- or degradation-related impurity, Palbociclib Impurity 118 (CAS 844843-37-4, C4H2BrClN2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Palbociclib Impurity 118 (C4H2BrClN2O) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Palbociclib Impurity 118 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H2BrClN2O |
| Molecular Weight | 209.43 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Palbociclib Standards
- Palbociclib Impurity 44 (CAS 82205-58-1)
- Palbociclib Impurity 149 (CAS CATO-C4X-1125149)
- Palbociclib Impurity 82 (CAS 1566082-34-5)
- Palbociclib Impurity 83 (CAS 1211541-02-4)
- Palbociclib Impurity 97 (CAS 775288-71-6)
- Palbociclib Impurity 180 (CAS 2777066-29-0)
- Palbociclib Impurity 43 (CAS 51534-82-8)
- Palbociclib Impurity 172 (CAS CATO-C4X-1125172)
Recommended Standards
- 5-Bromo-6-chloro-4-pyrimidone (CAS 89089-19-0)
- 1-Bromo-2-chloro-4-fluorobenzene (CAS 110407-59-5)
- 5-Bromo-2-furoyl chloride (CAS 26726-16-9)
- 1-Bromo-3-chloro-2-fluorobenzene (CAS 144584-65-6)
- Gefapixant Impurity 5 (CAS CATO-C4X-28495)
- Paroxetine Hydrochloride Hemihydrate EP Impurity F (CAS 2105932-71-4)
- Tedizolid Impurity 6 (CAS 856867-41-9)
- Vitexicarpin (CAS 479-91-4)
- Tetrahydropyran-2-methanol (CAS 100-72-1)
- 2-Chloro-N-(2-ethoxyethyl)-N-(m-tolyl)acetamide (CAS 70439-13-3)
- 1-(4-nitrophenyl)-5-oxo-4,5-dihydro-1H-pyrazole-3-carboxylic acid (CAS 62084-02-0)
- 2-(4-Acetylphenyl)acetic acid (CAS 7398-52-9)
- Ethyl 3-((6-(benzo[d][1,3]dioxol-5-yl)-3-cyano-4-(trifluoromethyl)pyridin-2-yl)thio)propanoate (CAS 625376-94-5)
- Peptide 442 (CAS CATO-CPTD788442)
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