2-(Trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-one CAS 338739-97-2
| CAS No. | 338739-97-2 |
| Molecular Formula | C8H4F3N3O |
| Molecular Weight | 215.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(Trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-one (CAS 338739-97-2) is a high-purity analytical reference standard with the molecular formula C8H4F3N3O and a molecular weight of 215.13 g/mol.
2-(Trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-one (C8H4F3N3O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4F3N3O |
| Molecular Weight | 215.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Trifluoromethyl Standards
- 7-(Trifluoromethyl)pyrido[3,2-d]pyrimidin-4(3H)-one (CAS 1429870-20-1)
- 2-(Trifluoromethyl)-4H-benzo[d][1,3]oxazin-4-one (CAS 16062-71-8)
- 6-(Trifluoromethyl)benzo[d][1,2,3]triazin-4(3H)-one (CAS 1802389-77-0)
- 4-(Trifluoromethyl)indoline-2,3-dione (CAS 386-73-2)
- 5-(Trifluoromethyl)phthalimide (CAS 1997-41-7)
- 6-(Trifluoromethyl)-1H-imidazo[4,5-b]pyridine-2-carbaldehyde (CAS 944904-88-5)
- 6-(Trifluoromethyl)benzo[d]oxazole-2-carbaldehyde (CAS 944898-85-5)
- 6-(Trifluoromethyl)isatin (CAS 343-69-1)
Recommended Standards
- 1-Nitro-4-(3,3,3-trifluoro-1-propyn-1-yl)-benzene (CAS 1983-22-8)
- 2,2,2-Trifluoro-1-(imidazo[1,2-a]pyrimidin-3-yl)ethanone (CAS 691372-19-7)
- 1-Ethynyl-3-nitro-5-(trifluoromethyl)benzene (CAS 2228611-47-8)
- 2-Cyano-4-(trifluoromethyl)benzoic acid (CAS 779-16-8)
- 2-Chloro-5-(difluoromethyl)pyridine 6-Chloro-3-(difluoromethyl)pyridine 71701-99-0 (CAS 71701-99-0)
- Benzyl (E)-2-(3-(3,4-dichlorophenoxy)prop-1-en-1-yl)pyrrolidine-1-carboxylate (CAS 956190-12-8)
- Phenobarbital N-β-D-glucuronide (CAS 1031858-68-0)
- (3R,4S)-4-(p-Tolyl)pyrrolidine-3-carboxylic acid (CAS 1260601-83-9)
- 3-Hydroxy-3-(4-(trifluoromethoxy)phenyl)propanenitrile (CAS 1520504-56-6)
- 1-(Pyridin-2-yl)propane-1,3-diol (CAS 213248-46-5)
- Ethyl 4-[(mercaptoacetyl)amino]benzoate (CAS 99254-22-5)
- 4-Bromo-3-chloro-6-(difluoromethyl)pyridine-2-carboxylic acid (CAS 1805034-19-8)
- 1,3,5-Trimethyl-1H-pyrazole-4-carboxamide (CAS 861586-14-3)
- Semaglutide impurity 271 (CAS CATO-C4X-2226271)
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