(4Z)-1-(4-Chlorophenyl)-3-ethoxy-4-({[3-(trifluoromethyl)phenyl]amino}methylidene)-4,5-dihydro-1H-pyrazol-5-one CAS 338751-18-1
| CAS No. | 338751-18-1 |
| Molecular Formula | C19H15ClF3N3O2 |
| Molecular Weight | 409.79 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 409.79 g/mol gives (4Z)-1-(4-Chlorophenyl)-3-ethoxy-4-({[3-(trifluoromethyl)phenyl]amino}methylidene)-4,5-dihydro-1H-pyrazol-5-one distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
(4Z)-1-(4-Chlorophenyl)-3-ethoxy-4-({[3-(trifluoromethyl)phenyl]amino}methylidene)-4,5-dihydro-1H-pyrazol-5-one (CAS 338751-18-1), molecular formula C19H15ClF3N3O2 and molecular weight 409.79 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (4Z)-1-(4-Chlorophenyl)-3-ethoxy-4-({[3-(trifluoromethyl)phenyl]amino}methylidene)-4,5-dihydro-1H-pyrazol-5-one (C19H15ClF3N3O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H15ClF3N3O2 |
| Molecular Weight | 409.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Z Standards
- 3-(2-Chlorophenyl)-N-{[3-(4-methoxyphenyl)-1,2-oxazol-5-yl]methyl}-1,2-oxazole-5-carboxamide (CAS 338750-11-1)
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Recommended Standards
- 4-Chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 1830311-70-0)
- 1,3-Diethyl 2-{[(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)amino]methylidene}propanedioate (CAS 337920-38-4)
- Ethyl 2-((2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-fluoro-6-methylpyrimidin-4-yl)thio)acetate (CAS 1823183-41-0)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[(4-methoxyphenyl)methyl]-1H-pyrrole-2-carboxamide (CAS 338397-63-0)
- 1-(4-Iodobenzyl)-1H-pyrazole (CAS 143128-30-7)
- 2,3-Difluoro-5-(trifluoromethoxy)benzodifluoride (CAS 1806372-49-5)
- (2-(Pyrrolidin-1-yl)-5,6,7,8-tetrahydroquinolin-3-yl)methanamine (CAS 1282243-32-6)
- 3-{[(Furan-2-ylmethyl)-amino]-methyl}-7-methyl-1H-quinolin-2-one (CAS 333411-66-8)
- (2-bromoethyl)dipropylamine hydrobromide (CAS 22511-39-3)
- 2-(Chloromethyl)-4,5-dimethyl-3,6-dihydro-2h-pyran (CAS 98559-77-4)
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