(4Z)-1-(4-Chlorophenyl)-4-{[(2,4-difluorophenyl)amino]methylidene}-3-ethoxy-4,5-dihydro-1H-pyrazol-5-one CAS 338751-17-0
| CAS No. | 338751-17-0 |
| Molecular Formula | C18H14ClF2N3O2 |
| Molecular Weight | 377.77 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (4Z)-1-(4-Chlorophenyl)-4-{[(2,4-difluorophenyl)amino]methylidene}-3-ethoxy-4,5-dihydro-1H-pyrazol-5-one is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(4Z)-1-(4-Chlorophenyl)-4-{[(2,4-difluorophenyl)amino]methylidene}-3-ethoxy-4,5-dihydro-1H-pyrazol-5-one (CAS 338751-17-0) is a high-purity analytical reference standard with the molecular formula C18H14ClF2N3O2 and a molecular weight of 377.77 g/mol.
The molecular framework of (4Z)-1-(4-Chlorophenyl)-4-{[(2,4-difluorophenyl)amino]methylidene}-3-ethoxy-4,5-dihydro-1H-pyrazol-5-one (C18H14ClF2N3O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H14ClF2N3O2 |
| Molecular Weight | 377.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Z Standards
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Recommended Standards
- Benzenecarbothioicacid,[(2-hydroxyphenyl)methylene]hydrazide,palladiumcomplex (CAS 132829-27-7)
- (E)-1-methyl-5-(phenylthio)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde O-(2-chloroacetyl) oxime (CAS 477711-22-1)
- 5-(((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-N-((dimethylamino)methylene)-4,5-dihydroisoxazole-3-carboxamide (CAS 321432-30-8)
- 2-(1-(2-Chloroacetyl)-3-oxopiperazin-2-yl)-N-(3-(trifluoromethyl)phenyl)acetamide (CAS 1306738-22-6)
- Imidazo[5,1-b]thiazole-3-carboxylic acid hydrochloride (CAS 2137605-31-1)
- 1-(4-Chlorophenyl)-2-((5-ethyl-1h-1,2,4-triazol-3-yl)thio)ethan-1-one (CAS 67944-07-4)
- , N-butyltetrahydro-3-Thiophenamine-1,1-dioxide, hydrochloride (1:1) (CAS 76924-22-6)
- 2-Bromo-1-(2-(pyrrolidin-1-yl)-1H-imidazol-4-yl)ethanone (CAS 88723-66-4)
- Methyl (R)-4-(1H-indol-3-yl)-2-methylbutanoate (CAS 97399-93-4)
- (2-Isopropyltetrahydro-2H-pyran-3-yl)methanamine hydrochloride (CAS 1375969-06-4)
- sec-Butyl 4-(2,3-dimethoxyphenyl)-2-methyl-5-oxo-7-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (CAS 5717-61-3)
- N,N'-(4,4'-methylenebis(4,1-phenylene))bis(2,2,2-trichloroacetamide) (CAS 550299-55-3)
- 2,6-Dibromo-4-cyclopentylthiazolo[5,4-b]pyridin-5(4H)-one (CAS 1956380-01-0)
- Semaglutide impurity 72 (CAS CATO-C4X-222672)
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