6-Phenyl-3-[3-(trifluoromethyl)phenoxy]-4-pyridazinecarbonitrile CAS 338751-76-1
| CAS No. | 338751-76-1 |
| Molecular Formula | C18H10F3N3O |
| Molecular Weight | 341.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 6-Phenyl-3-[3-(trifluoromethyl)phenoxy]-4-pyridazinecarbonitrile (C18H10F3N3O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
6-Phenyl-3-[3-(trifluoromethyl)phenoxy]-4-pyridazinecarbonitrile (CAS 338751-76-1), molecular formula C18H10F3N3O and molecular weight 341.29 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H10F3N3O |
| Molecular Weight | 341.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Phenyl Standards
- 2-{[4-(trifluoromethyl)-2-pyridyl]oxy}ethyl 4-methoxybenzoate (CAS 257624-96-7)
- Ethyl 2-(1-(3-(trifluoromethyl)benzoyl)piperidin-4-ylidene)acetate (CAS 439095-20-2)
- (2Z)-2-{[2-(trifluoromethyl)phenyl]methylidene}-2,3,4,9-tetrahydro-1H-carbazol-1-one (CAS 866149-09-9)
- 8-(3,5-Bis(trifluoromethyl)benzyl)-2,5-dioxa-8-azaspiro[3.4]Octane (CAS 1556097-36-9)
- 2-((3,5-Bis(trifluoromethyl)phenyl)carbamoyl)cyclopropane-1-carboxylic acid (CAS 1024329-33-6)
- 2,6-Bis(trifluoromethyl)pyridine-4-boronic Acid Pinacol Ester (CAS 1320747-32-7)
- 4-Methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-sulfonyl chloride (CAS 568577-83-3)
- 1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate (CAS 320423-26-5)
Recommended Standards
- 5-(4-Methoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylic acid (CAS 312935-05-0)
- N-(5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide (CAS 897734-98-4)
- 5-(3-Methoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid (CAS 667921-14-4)
- 4-[(E)-2-(2,4-Dichlorophenyl)ethenyl]-2-(ethylsulfanyl)-6,6-dimethyl-1,6-dihydropyrimidine (CAS 1164553-16-5)
- Dicyclohexylmethane (CAS 3178-23-2)
- 4-Ethyl-5-propyl-4h-1,2,4-triazole-3-thiol (CAS 51590-52-4)
- 1-(4-Hydroxyphenyl)-2,2-dimethylpropan-1-one (CAS 72569-10-9)
- (2-(Benzo[d]thiazol-2-yl)pyridin-3-yl)(2-methylpiperidin-1-yl)methanone (CAS 873857-03-5)
- tert-Butyl 4-((5-fluoropyrimidin-2-yl)amino)piperidine-1-carboxylate (CAS 1261233-23-1)
- (2-Chloro-5-(1H-pyrrol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone (CAS 1190266-08-0)
- Methyl (R)-3-amino-3-(2-chloro-5-methylphenyl)propanoate (CAS 1212868-28-4)
- 5-(3-bromophenyl)-1h-pyraZole-3-carbohydrazide (CAS 1046463-50-6)
- Thioctic acid Impurity 38 (CAS 5238-47-1)
- Lixisenatide (CAS 320367-13-3)
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