N-Methyl-2-oxo-1-{[3-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carboxamide CAS 338754-78-2
| CAS No. | 338754-78-2 |
| Molecular Formula | C15H13F3N2O2 |
| Molecular Weight | 310.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), N-Methyl-2-oxo-1-{[3-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
N-Methyl-2-oxo-1-{[3-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carboxamide (CAS 338754-78-2), molecular formula C15H13F3N2O2 and molecular weight 310.27 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-Methyl-2-oxo-1-{[3-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carboxamide (C15H13F3N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C15H13F3N2O2 |
| Molecular Weight | 310.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- Niflumic Acid Ethyl Ester (CAS 51703-19-6)
- N-Methyl-2-oxo-1-{[4-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carboxamide (CAS 338781-83-2)
- N-{3-[4-Amino-3-(trifluoromethyl)phenoxy]-phenyl}acetamide (CAS 946698-12-0)
- N-methyl-6-oxo-1-(3-(trifluoromethyl)benzyl)-1,6-dihydropyridine-3-carboxamide (CAS 338783-59-8)
- Methyl 6-(benzyloxy)-5-methoxybenzo[b]thiophene-2-carboxylate (CAS 1263211-11-5)
- 2-(((1-Phenyl-1H-pyrazol-4-yl)methyl)amino)quinazolin-4(3H)-one (CAS 1797130-82-5)
- 5,6-Dimethyl-2,5-dihydropyrazine-2-carboxylic acid (CAS 160532-38-7)
- Valganciclovir EP Impurity Q (CAS CATO-C4X-177420)
- 3-Amino-6-ethyl-2-methylthieno[2,3-d]pyrimidin-4(3H)-one (CAS 80381-61-9)
- Methotrexate EP Impurity I (CAS 66147-29-3)
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- 1-(4-(4-Fluorophenoxy)phenyl)ethan-1-amine hydrochloride (CAS 2138519-32-9)
- 2-(Aminomethyl)isonicotinonitrile (CAS 1060809-90-6)
- Semaglutide impurity 45 (CAS CATO-C4X-222645)
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