8-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethyl)phenyl)-1-oxa-4,8-diazaspiro[4.5]Decane-4-carboxamide CAS 338761-28-7
| CAS No. | 338761-28-7 |
| Molecular Formula | C21H19ClF6N4O2 |
| Molecular Weight | 508.84 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO supplies 8-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethyl)phenyl)-1-oxa-4,8-diazaspiro[4.5]Decane-4-carboxamide (CAS 338761-28-7), a certified reference material (molecular formula C21H19ClF6N4O2, MW 508.84 g/mol) for analytical method development and quality control.
8-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethyl)phenyl)-1-oxa-4,8-diazaspiro[4.5]Decane-4-carboxamide (C21H19ClF6N4O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H19ClF6N4O2 |
| Molecular Weight | 508.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- N-{2-[(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)amino]-5-(trifluoromethyl)phenyl}thiophene-2-carboxamide (CAS 478262-30-5)
- (2E)-1-[5-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}methyl)-4,5-dihydro-1,2-oxazol-3-yl]-3-{[4-(trifluoromethoxy)phenyl]amino}prop-2-en-1-one (CAS 344276-97-7)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-3-ethoxy-4-[(1E)-({[4-(trifluoromethyl)phenyl]methoxy}imino)methyl]-1H-pyrazol-5-ol (CAS 324009-23-6)
- 1-(3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-3-(2-cyano-4,5-dimethoxyphenyl)thiourea (CAS 343375-06-4)
- 4-Chloro-5-iodo-N,N-bis[(4-methoxyphenyl)methyl]-6-methyl-pyridin-2-amine (CAS 2763159-74-4)
- 2-Chloro-1,3,5-tris((trifluoromethyl)sulfonyl)benzene (CAS 71601-85-9)
- (2E)-1-(3-{3-[(2-chloro-6-fluorophenyl)methoxy]phenyl}-1H-pyrazol-1-yl)-3-[4-(3-fluoropropoxy)phenyl]prop-2-en-1-one (CAS 477711-76-5)
- N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-((3-(4-methoxyphenyl)-2-methylisoxazolidin-5-yl)methyl)-N'-methylmethanesulfonohydrazide (CAS 339276-44-7)
Recommended Standards
- (βS,1R,3aS,4E,7aR)-4-[[(6S)-6-[[(tert-Butyldimethylsilyloxy]-1,3,4,5,6,7-hexahydro-2,2-dioxidobenzo[c]thien-1-yl]methylene]octahydro-β,7a-dimethyl-1H-Indene-1-ethanol (CAS 344798-31-8)
- 1025301-37-4 2-((4-Chlorophenyl)sulfonyl)-3-(5-nitro-2-(3-(trifluoromethyl)phenoxy)phenyl)prop-2-enenitrile MFCD00245587 (CAS 1025301-37-4)
- Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxododecyl)-.omega.-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]- (CAS 58258-44-9)
- 2,3,4-Trichloro-N-(5,6-dimethyl-1-(3-methylbenzyl)-1H-benzo[d]imidazol-4-yl)benzenesulfonamide (CAS 338423-59-9)
- (1-(4-Methoxyphenethyl)-1H-1,2,3-triazol-4-yl)methanol (CAS 1283653-08-6)
- 31886-51-8 Nickel(2+) bis(2-ethylcyclopenta-1,3-dien-1-ide) DTXSID40628000 (CAS 31886-51-8)
- 3-((Furan-2-ylmethyl)thio)azetidine hydrochloride (CAS 1864072-43-4)
- 3-Amino-N-(3,5-dichlorophenyl)benzamide (CAS 176032-83-0)
- 3-{[3-(4-methoxyphenyl)-1,2-oxazol-5-yl]methoxy}naphthalene-2-carboxylic acid (CAS 949426-13-5)
- (3S,8AS)-3-methylhexahydropyrrolo[1,2-a]pyrazin-4(1H)-one hydrochloride (CAS 2230901-11-6)
- Atogepant Impurity 12 (CAS CATO-C4X-328512)
- 2-(3-Fluoro-4-methylphenyl)-2-hydroxyacetic acid (CAS 1214328-14-9)
- 2'-Deoxythymidinee-5'-O-(α-thio)triphosphate (CAS 99749-43-6)
- Insulin Degludec Impurity 17 (CAS CATO-C4X-215717)
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