5-Acetyl-1-(4-chlorophenyl)-3-(4-fluorobenzyl)pyrimidine-2,4(1H,3H)-dione CAS 338770-01-7
| CAS No. | 338770-01-7 |
| Molecular Formula | C19H14ClFN2O3 |
| Molecular Weight | 372.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 5-Acetyl-1-(4-chlorophenyl)-3-(4-fluorobenzyl)pyrimidine-2,4(1H,3H)-dione (CAS 338770-01-7), a certified reference material (molecular formula C19H14ClFN2O3, MW 372.78 g/mol) for analytical method development and quality control.
The molecular framework of 5-Acetyl-1-(4-chlorophenyl)-3-(4-fluorobenzyl)pyrimidine-2,4(1H,3H)-dione (C19H14ClFN2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Acetyl-1-(4-chlorophenyl)-3-(4-fluorobenzyl)pyrimidine-2,4(1H,3H)-dione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H14ClFN2O3 |
| Molecular Weight | 372.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Acetyl Standards
- N-(2-Chlorophenyl)-1-((4-fluorobenzyl)oxy)-2-oxo-1,2-dihydropyridine-3-carboxamide (CAS 868678-07-3)
- 2-(4-Chlorophenyl)-5-phenyl-3-(trifluoromethyl)benzofuran (CAS 821770-02-9)
- N-(4-Chlorophenyl)-2-nitro-N-{[3-oxo-2-benzofuran-1(3H)-yliden]methyl}ethanimidohydrazide (CAS 1164476-34-9)
- 3-(2-Chlorophenyl)-5-methyl-N-(2-phenoxyethoxy)-1,2-oxazole-4-carboxamide (CAS 338406-47-6)
- 2-[(4-Chlorophenyl)methyl]-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1H,2H,3H,5H,6H,7H,8H-pyrido[1,2-c]pyrimidine-1,3-dione (CAS 1775503-16-6)
- Methyl 4-((4-chlorophenyl)thio)-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylate (CAS 320419-43-0)
- Methyl 5-[(4-chlorophenyl)sulfanyl]-4-formyl-1-phenyl-1H-pyrazole-3-carboxylate (CAS 449778-53-4)
- N-(4-(4-Chlorophenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide (CAS 515841-78-8)
Recommended Standards
- 4-Chloro-N-(3-(4-fluorobenzyl)-4-hydroxy-2-oxopyridin-1(2H)-yl)benzamide (CAS 477846-11-0)
- Methyl (E)-3-(2-chloro-6-fluorophenyl)-5-(2-(phenylamino)vinyl)isoxazole-4-carboxylate (CAS 338417-56-4)
- 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl 3,3-dimethylbutan-2-yl methylphosphonate (CAS 875577-99-4)
- PF-6274484 (CAS 1035638-91-5)
- 3,4-Bis(dimethylamino)cyclobut-3-ene-1,2-dithione (CAS 54131-92-9)
- N-Cyclobutyl-3-methyl-2,3-dihydro-1H-inden-1-amine (CAS 1220039-92-8)
- 2-(4-Bromo-1H-pyrrol-2-yl)acetonitrile (CAS 62380-96-5)
- 1-(1-ethylpiperidin-4-yl)piperidine-4-carboxylic acid dihydrochloride (CAS 1803587-26-9)
- CH 223191 (CAS 301326-22-7)
- (4-(Propoxymethyl)tetrahydro-2h-pyran-4-yl)methanesulfonyl chloride (CAS 1485708-44-8)
- 7,7-Dimethyl-7H-pyrrolo[3,4-d]pyrimidine (CAS 13797-06-3)
- Polylactic Acid (CAS 31852-84-3)
- 4-Hydroxy-4-(2-hydroxyethyl)tetrahydro-2H-thiopyran 1,1-dioxide (CAS 2090778-05-3)
- Semaglutide impurity 42 (CAS CATO-C4X-222642)
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