4-(4-Fluorophenoxy)-5-methoxy-2-(pyridin-2-yl)pyrimidine CAS 338771-33-8
| CAS No. | 338771-33-8 |
| Molecular Formula | C16H12FN3O2 |
| Molecular Weight | 297.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-(4-Fluorophenoxy)-5-methoxy-2-(pyridin-2-yl)pyrimidine is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-(4-Fluorophenoxy)-5-methoxy-2-(pyridin-2-yl)pyrimidine (CAS 338771-33-8) is a high-purity analytical reference standard with the molecular formula C16H12FN3O2 and a molecular weight of 297.28 g/mol.
Structurally, 4-(4-Fluorophenoxy)-5-methoxy-2-(pyridin-2-yl)pyrimidine (C16H12FN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 297.28 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H12FN3O2 |
| Molecular Weight | 297.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Fluorophenoxy Standards
- Ethyl 2-(2-((4-fluorophenoxy)methyl)morpholino)acetate (CAS 1706446-42-5)
- trans-3-(4-Fluorophenoxy)-4-hydroxy-1-Boc-pyrrolidine (CAS 1951440-06-4)
- 1-(2-(2-Fluorophenoxy)ethyl)-2-methyl-1H-indole-3-carbaldehyde (CAS 432003-58-2)
- 6-(4-Fluorophenoxy)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 343372-96-3)
- 2-(4-Fluorophenoxy)-N-(pyridin-3-yl)ethane-1-sulfonamide (CAS 1351658-60-0)
- 4-(4-Fluorophenoxy)-5-methoxy-2-phenylpyrimidine (CAS 860788-29-0)
- 5-(3-Fluorophenoxy)-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (CAS 926205-25-6)
- 4-(5-((4-Fluorophenoxy)methyl)-1,2,4-oxadiazol-3-yl)benzaldehyde (CAS 1119450-77-9)
Recommended Standards
- 4-(3-[3-(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl)piperidine (CAS 808764-45-6)
- 5-(2-methoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (CAS 677311-06-7)
- 3-Fluoro-N-((3-phenyl-1,2,4-oxadiazol-5-yl)methyl)benzamide (CAS 838867-01-9)
- 5-(4-methoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (CAS 861233-52-5)
- 4-(4-Fluorophenyl)-1-methoxyisoquinolin-5-ol (CAS 656233-90-8)
- 2-{4-[(4-methylphenyl)methyl]piperazin-1-yl}acetohydrazide (CAS 893726-97-1)
- 6-(Morpholinomethyl)pyridine-3-boronic Acid (CAS 934505-32-5)
- 3-Bromo-4-methylbenzene-1-sulfonyl chloride (CAS 1029145-99-0)
- 2-(Benzylamino)-N-(2-methoxy-5-methylphenyl)-2-thioxoacetamide (CAS 329078-92-4)
- 2-(Dimethylphosphinyl)phenol (CAS 1333230-31-1)
- 3-Ethynyl-5-(trifluoromethyl)pyridin-2-amine (CAS 1048914-02-8)
- Saikosaponin A (CAS 20736-09-8)
- 2-Chloro-N-ethyl-N-((1-methylpiperidin-2-yl)methyl)acetamide (CAS 1353974-71-6)
- Hexapeptide-9 (CAS 1228371-11-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com