1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-3-(phenylsulfanyl)pyrrolidine-2,5-dione CAS 338772-49-9
| CAS No. | 338772-49-9 |
| Molecular Formula | C17H13ClF3N3O2S |
| Molecular Weight | 415.82 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-3-(phenylsulfanyl)pyrrolidine-2,5-dione is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-3-(phenylsulfanyl)pyrrolidine-2,5-dione (CAS 338772-49-9), a certified reference material (molecular formula C17H13ClF3N3O2S, MW 415.82 g/mol) for analytical method development and quality control.
The molecular framework of 1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-3-(phenylsulfanyl)pyrrolidine-2,5-dione (C17H13ClF3N3O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-3-(phenylsulfanyl)pyrrolidine-2,5-dione under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C17H13ClF3N3O2S |
| Molecular Weight | 415.82 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related chloro Standards
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(p-tolyl)-1H-pyrrole-2-sulfonamide (CAS 321433-64-1)
- Methyl 2-[(5-chloro-2-{[(1Z)-2-cyano-2-{[(ethoxycarbonyl)amino]carbonyl}eth-1-en-1-yl]amino}-3-fluorophenyl)sulfanyl]acetate (CAS 400078-03-7)
- N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N'-methylnaphthalene-2-sulfonohydrazide (CAS 338748-70-2)
- 3-(2-Chloro-6-fluorophenyl)-5-methyl-4-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]-1,2-oxazole (CAS 287176-94-7)
- 4-(2-Chloro-4-fluorobenzyl)-1-{[6-(trifluoromethyl)-3-pyridinyl]methyl}-1,4-diazepan-5-one (CAS 909668-92-4)
- N-(2-chloro-5-(trifluoromethyl)phenyl)-2-(4-(2-fluorophenyl)piperazin-1-yl)acetamide (CAS 329779-24-0)
- N-(2-chloro-5-(trifluoromethyl)phenyl)-2-(4-(4-fluorophenyl)piperazin-1-yl)acetamide (CAS 882082-22-6)
- N-(3-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)(hydroxy)methyl)-2,4-difluorophenyl)propane-1-sulfonamide (CAS 1021854-28-3)
Recommended Standards
- 3-[(E)-1-(4-Chlorophenyl)-2-(dimethylamino)ethenesulfonyl]-5-(trifluoromethyl)pyridine-2-carbonitrile (CAS 551930-73-5)
- 5-((4-Chlorophenyl)sulfonyl)-N-(2,4-difluorophenyl)-1,2,3-thiadiazole-4-carboxamide (CAS 672951-17-6)
- Acemetacin (CAS 53164-05-9)
- Arhalofenate (CAS 24136-23-0)
- (2-Methyloctahydrocyclopenta[c]pyrrole-4,6-diyl)dimethanol (CAS 18853-60-6)
- Rubidium perchlorate, anhydrous (99.9%-Rb) (CAS 13510-42-4)
- 5-Methoxypyrimidine (CAS 31458-33-0)
- (5-(4-Amino-2-methoxyphenyl)furan-2-yl)methanol (CAS 727421-95-6)
- Pyrotinib Dimaleate (CAS 1397922-61-0)
- 123855-53-8 2947AD 4-{[(4-Fluorobenzyl)oxy]methyl}piperidinehydrochloride C13H19ClFNO (CAS 123855-53-8)
- 1311283-69-8 N'-[[6-Chloro-4-(trifluoromethyl)-2-pyridyl]-methyl-amino]-N,N-dimethyl-formamidine MFCD19981167 (CAS 1311283-69-8)
- tert-Butyl 2-(6-(isobutylamino)pyridin-3-yl)pyrrolidine-1-carboxylate (CAS 1352509-36-4)
- 5-Bromo-6-(dimethylamino)nicotinonitrile (CAS 1782649-97-1)
- Tirzepatide Impurity 36 (CAS CATO-C4X-324036)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com