(E)-2-(3-((4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)amino)-1-(dimethylamino)allylidene)malononitrile CAS 338773-53-8
| CAS No. | 338773-53-8 |
| Molecular Formula | C20H15ClF3N5O |
| Molecular Weight | 433.81 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies (E)-2-(3-((4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)amino)-1-(dimethylamino)allylidene)malononitrile (CAS 338773-53-8), a certified reference material (molecular formula C20H15ClF3N5O, MW 433.81 g/mol) for analytical method development and quality control.
(E)-2-(3-((4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)amino)-1-(dimethylamino)allylidene)malononitrile (C20H15ClF3N5O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (E)-2-(3-((4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)amino)-1-(dimethylamino)allylidene)malononitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H15ClF3N5O |
| Molecular Weight | 433.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related E Standards
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-5,5'-dimethyl-2'-phenyl-1',2'-dihydro-2H,3'H-[3,4'-bipyrazol]-3'-one (CAS 318951-76-7)
- 2-[(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)amino]-4-(dimethylamino)pyridine-3-carbonitrile (CAS 338773-57-2)
- 3-Chloro-N-{[3-(2-phenylpyrimidin-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}-5-(trifluoromethyl)pyridin-2-amine (CAS 344277-17-4)
- Ethyl 1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-3-(1H-pyrrol-1-yl)-1H-indole-2-carboxylate (CAS 339099-02-4)
- N-(3-Chloro-4-fluorophenyl)-2-[4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H-pyrido[1,2-c]pyrimidin-2-yl]acetamide (CAS 1775345-25-9)
- 2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-4-(thiophen-2-yl)pyrimidine (CAS 477862-43-4)
- 2-Chloro-N-(4-((2-cyano-5-(trifluoromethyl)pyridin-3-yl)thio)phenyl)benzamide (CAS 338419-94-6)
- Ethyl 2-{[(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)carbamothioyl]amino}acetate (CAS 477873-14-6)
Recommended Standards
- N-(1-benzylpiperidin-4-yl)-2,4,5-trichlorobenzenesulfonamide (CAS 334974-49-1)
- Ethyl 5-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)-4,6-dioxo-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrazole-3-carboxylate (CAS 317821-61-7)
- N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N'-methyl-3-(trifluoromethyl)benzenesulfonohydrazide (CAS 339276-25-4)
- 2-Chloro-1-[7-(4-chloro-benzylidene)-3-(4-chloro-phenyl)-3,3a,4,5,6,7-hexahydro-indazol-2-yl]-ethanone (CAS 325724-47-8)
- 6-benzyl-2-chloro-8-ethyl-7,8-dihydro-5H-1,6-naphthyridine (CAS 2758498-27-8)
- n-(2-Chlorobenzyl)-3-ethoxypropan-1-amine (CAS 705955-72-2)
- Isothiazole-4-carbonitrile (CAS 3912-37-6)
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- 1-(4-Bromophenyl)-3-((3-chloro-4-methylphenyl)amino)propan-1-one (CAS 477334-04-6)
- 2,4,6-Tribromophenylboronic acid (CAS 1451392-84-9)
- (S)-1-(4-Iodo-5-methoxy-2-nitrophenyl)-2,2-dimethylpropan-1-ol (CAS 1427311-76-9)
- 4-chloro-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid 9H-fluoren-9-ylmethyl ester 916420-25-2 9H-fluoren-9-ylmethyl 4-chloranyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate A844013 (CAS 916420-25-2)
- 4-(Furan-2-yl)-3-methyl-4,5-dihydro-1H-pyrazole (CAS 90006-91-0)
- Des-Pro36-37-Tirzepatide (CAS CATO-CPTD788938)
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