(2E)-2-{4-[5-(2,4-dichlorophenyl)furan-2-yl]-1,3-thiazol-2-yl}-3-(dimethylamino)prop-2-enenitrile CAS 338786-21-3
| CAS No. | 338786-21-3 |
| Molecular Formula | C18H13Cl2N3OS |
| Molecular Weight | 390.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (2E)-2-{4-[5-(2,4-dichlorophenyl)furan-2-yl]-1,3-thiazol-2-yl}-3-(dimethylamino)prop-2-enenitrile.
(2E)-2-{4-[5-(2,4-dichlorophenyl)furan-2-yl]-1,3-thiazol-2-yl}-3-(dimethylamino)prop-2-enenitrile (CAS 338786-21-3), molecular formula C18H13Cl2N3OS and molecular weight 390.29 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (2E)-2-{4-[5-(2,4-dichlorophenyl)furan-2-yl]-1,3-thiazol-2-yl}-3-(dimethylamino)prop-2-enenitrile (C18H13Cl2N3OS) is characterized by a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H13Cl2N3OS |
| Molecular Weight | 390.29 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
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Recommended Standards
- ((2R,3S,4R,5R)-5-(6-Amino-8-(dimethylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate (CAS 61370-74-9)
- (R)-2-((5-bromothiophen-2-yl)methyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (CAS 959578-36-0)
- ((2R,3S,4R,5R)-5-(6-((2-Aminoethyl)amino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate (CAS 60915-31-3)
- ((2R,3S,4R,5R)-3,4-Dihydroxy-5-(6-hydroxy-2-propyl-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate (CAS 88868-95-5)
- N-(5-Acetyl-4-methylthiazol-2-yl)-2-(ethylthio)benzamide (CAS 898422-79-2)
- 1-(2-Cyclopropoxyphenyl)ethan-1-one (CAS 1129301-31-0)
- 4-Amino-2-isobutylpyridazin-3(2H)-one (CAS 1707585-69-0)
- 3-Methyl-1-(m-tolyl)-1H-pyrazol-5-ol (CAS 2235-75-8)
- 2-Chloro-4-cyclopropylbenzonitrile (CAS 1238709-08-4)
- Acifluorfen (CAS 50594-66-6)
- Ethyl 3-methyl-2H-azirine-2-carboxylate (CAS 14369-88-1)
- (R)-3-(5-Oxo-tetrahydro-furan-2-yl)-propionic acid (CAS 98611-86-0)
- (dodecylsulfanyl)-N-phenylmethanimidamide hydrobromide (CAS 1173621-67-4)
- FMRF-Like Peptide from snail Helix aspersa (CAS 98495-35-3)
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