2,2-Difluoro-2-(4-fluorophenoxy)-N-[3-(trifluoromethyl)phenyl]acetamide CAS 338792-39-5
| CAS No. | 338792-39-5 |
| Molecular Formula | C15H9F6NO2 |
| Molecular Weight | 349.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2,2-Difluoro-2-(4-fluorophenoxy)-N-[3-(trifluoromethyl)phenyl]acetamide (CAS 338792-39-5), molecular formula C15H9F6NO2 and molecular weight 349.23 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2,2-Difluoro-2-(4-fluorophenoxy)-N-[3-(trifluoromethyl)phenyl]acetamide (C15H9F6NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 349.23 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2,2-Difluoro-2-(4-fluorophenoxy)-N-[3-(trifluoromethyl)phenyl]acetamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H9F6NO2 |
| Molecular Weight | 349.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoro Standards
- 2,2-Difluoro-N-(2-fluorophenyl)-2-(3-(trifluoromethyl)phenoxy)acetamide (CAS 338792-22-6)
- 2,2-Difluoro-N-(4-fluorophenyl)-2-[3-(trifluoromethyl)phenoxy]acetamide (CAS 338792-00-0)
- 1,3-Difluoro-2-(2-methoxy-5-nitrophenoxy)-5-(trifluoromethyl)benzene (CAS 2244087-66-7)
- 1,3-Difluoro-2-(4-methoxy-2-nitrophenoxy)-5-(trifluoromethyl)benzene (CAS 2244085-13-8)
- 6,7-Difluoro-1-methyl-3-(m-tolylsulfonyl)quinolin-4(1H)-one (CAS 1326894-33-0)
- Butyl 6,8-difluoro-4-(piperazin-1-yl)quinoline-2-carboxylate (CAS 1951444-46-4)
- 1,2-Difluoro-4-[2-[(trans,trans)-4'-propyl[1,1'-bicyclohexyl]-4-yl]ethyl]-benzene (CAS 107215-66-7)
- 1,2-Difluoro-4-((1S,4R)-4-(2-((1S,4S)-4-propylcyclohexyl)ethyl)cyclohexyl)benzene (CAS 117943-37-0)
Recommended Standards
- 2-(1-(2,4-Dichlorophenyl)-3-oxo-3-(thiophen-2-yl)propyl)malononitrile (CAS 400737-44-2)
- 2-(((3R,4R)-3,4-Dihydroxy-2-oxo-5-(phosphonooxy)pentyl)amino)benzoic acid (CAS 5962-18-5)
- 1-Methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-benzo[d]imidazol-2-amine (CAS 330793-28-7)
- 2-Benzyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one (CAS 2221016-69-7)
- methyl 1-hydroxy-1,3-dihydro-2,1-benzoxaborole-6-carboxylate (CAS 1800305-79-6)
- 4-[(4-Methylphenyl)sulfanyl]-3-nitrobenzenecarbaldehyde oxime (CAS 477852-05-4)
- 1-(2-((4-Fluorophenyl)amino)-4-methylthiazol-5-yl)ethan-1-one (CAS 952183-69-6)
- 2-Methoxy-4-(4-methylpiperazinomethyl) benzophenone (CAS 898783-46-5)
- (E)-3-(5-bromo-2-((1-ethoxy-1-oxopropan-2-yl)oxy)phenyl)acrylic acid (CAS 937599-40-1)
- tert-Butyl (2S)-2-[[tert-butyl(diphenyl)silyl]oxymethyl]-5-oxopyrrolidine-1-carboxylate (CAS 138871-56-4)
- 5-Fluoro-2-(trifluoromethyl)benzoic acid (CAS 654-99-9)
- 1-Phenylhexan-2-one (CAS 25870-62-6)
- Benzyl (2S,4S)-4-methyl-5-oxo-2-phenyloxazolidine-3-carboxylate (CAS 171860-41-6)
- Semaglutide impurity 51 (CAS CATO-C4X-222651)
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