Ethyl 8-chloro-6-fluoro-4-hydroxyquinoline-3-carboxylate CAS 338795-20-3
| CAS No. | 338795-20-3 |
| Molecular Formula | C12H9ClFNO3 |
| Molecular Weight | 269.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Ethyl 8-chloro-6-fluoro-4-hydroxyquinoline-3-carboxylate (CAS 338795-20-3), molecular formula C12H9ClFNO3 and molecular weight 269.66 g/mol, is a CATO reference standard with documented purity and traceability.
Ethyl 8-chloro-6-fluoro-4-hydroxyquinoline-3-carboxylate (C12H9ClFNO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO manufactures Ethyl 8-chloro-6-fluoro-4-hydroxyquinoline-3-carboxylate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H9ClFNO3 |
| Molecular Weight | 269.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- 1-(2-Chloro-4-fluorobenzyl)-5-methyl-3-nitro-1h-pyrazole (CAS 1004643-55-3)
- Ethyl 5-chloro-8-fluoro-4-hydroxyquinoline-3-carboxylate (CAS 1019015-59-8)
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Recommended Standards
- Ethyl 7-chloro-8-fluoro-4-hydroxyquinoline-3-carboxylate (CAS 75001-54-6)
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- Norfloxacin Impurity C18 (CAS 70458-93-4)
- methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate (CAS 4415-09-2)
- (cis-9)-2-Hydroxy-17-oxo-octadecenoic Acid (CAS 1159977-44-2)
- N-methyl-3-(tetrahydrofuran-2-yl)propan-1-amine (CAS 7179-89-7)
- Methyl 2-acetamido-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (CAS 92539-89-4)
- Cefadroxil Monohydrate (CAS 66592-87-8)
- 8-Hydroxyquinoline-6-carbonitrile (CAS 1025556-12-0)
- 3-(((Benzyloxy)carbonyl)amino)isonicotinic acid (CAS 1340368-26-4)
- Glycerol phosphate calcium salt hydrate mixture of isomers of alpha- and beta-form, >=96% (calc. based on dry substance, T) (CAS 1336-00-1)
- 2-[2-(1H-pyrazol-1-yl)ethoxy]ethan-1-ol (CAS 1238621-93-6)
- 6-Bromo-3-iodo-4-methoxy-1H-indole (CAS 1642536-99-9)
- Des-Trp25-Tirzepatide (CAS CATO-CPTD788948)
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