N-(2,4-Dichloro-5-methoxyphenyl)-4-methylbenzenesulfonamide CAS 338961-05-0
| CAS No. | 338961-05-0 |
| Molecular Formula | C14H13Cl2NO3S |
| Molecular Weight | 346.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
N-(2,4-Dichloro-5-methoxyphenyl)-4-methylbenzenesulfonamide (CAS 338961-05-0) is a high-purity analytical reference standard with the molecular formula C14H13Cl2NO3S and a molecular weight of 346.23 g/mol.
The molecular framework of N-(2,4-Dichloro-5-methoxyphenyl)-4-methylbenzenesulfonamide (C14H13Cl2NO3S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H13Cl2NO3S |
| Molecular Weight | 346.23 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related N Standards
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- 2,4-Dichloro-5-(isopropoxycarbonyl)phenyl pyrrolidine-1-carboxylate (CAS 133636-96-1)
- 2-(2,5-Dichloro-benzenesulfonylamino)-benzoic acid (CAS 309279-72-9)
- 4,5-Dichloro-2-[(2Z)-2-(4-chlorophenyl)-2-(methoxyimino)ethyl]-2,3-dihydropyridazin-3-one (CAS 477855-41-7)
- 3,5-dichloro-4-[(dimethylcarbamoyl)methoxy]benzene-1-sulfonyl chloride (CAS 1557293-38-5)
- 1,5-Dichloro-3-(ethoxymethoxy)-2-iodobenzene (CAS 1028332-20-8)
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Recommended Standards
- 4-(3,4-Dichlorophenyl)-N,N-dimethyl-5-(methylsulfonyl)pyrimidin-2-amine (CAS 251307-31-0)
- Ceritinib Impurity 13 (CAS CATO-C4X-104813)
- 2-Oxo-6-(trifluoromethyl)-1-{[3-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carbonitrile (CAS 338977-72-3)
- Ceritinib Impurity 14 (CAS CATO-C4X-104814)
- 2-methoxy-N,2-dimethylpropanimidamide hydrochloride (CAS 2060021-59-0)
- 2-(Acetylamino)-4-pentynoic acid (CAS 23234-80-2)
- 3-amino-1$l^{6}-benzothiophene-1,1-dione (CAS 858819-96-2)
- 1-Amino-3-(methylthio)propan-2-ol (CAS 1183494-17-8)
- 2-(tert-Butyl)-1-(2-chloroethyl)-1H-benzo[d]imidazo[1,2-a]imidazole (CAS 301164-08-9)
- 2',3-Dimethyl-[1,1'-biphenyl]-2-amine (CAS 854305-91-2)
- Ethyl4-(piperidin-4-yl)butanoatehydrochloride (CAS 473987-07-4)
- 3-(hydroxyimino)-3,4-dihydro-2H-benzo[b][1,4]thiazin-2-one (CAS 903891-96-3)
- 3-(Ethanesulfonyl)-n'-hydroxypropanimidamide (CAS 1216372-52-9)
- Polymyxin B nonapeptide (CAS 86408-36-8)
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