Ceritinib Impurity 14 CAS CATO-C4X-104814
| CAS No. | CATO-C4X-104814 |
| Molecular Formula | C13H13Cl2N3O2S |
| Molecular Weight | 346.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ceritinib Impurity 14 (C13H13Cl2N3O2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies Ceritinib Impurity 14 (CAS CATO-C4X-104814), a pharmacopoeial impurity reference standard (molecular formula C13H13Cl2N3O2S, MW 346.23 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H13Cl2N3O2S |
| Molecular Weight | 346.23 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Ceritinib Standards
- Ceritinib Impurity 13 (CAS CATO-C4X-104813)
- Ceritinib Impurity 80 (CAS CATO-C4X-104880)
- Ceritinib Impurity 57 (CAS CATO-C4X-104857)
- Ceritinib Impurity 56 (CAS CATO-C4X-104856)
- Ceritinib Impurity 58 (CAS CATO-C4X-104858)
- Ceritinib Impurity 33 (CAS CATO-C4X-104833)
- Ceritinib Impurity 16 (CAS CATO-C4X-1048916)
- Ceritinib Impurity 26 (CAS CATO-C4X-104826)
Recommended Standards
- N-(2,4-Dichloro-5-methoxyphenyl)-4-methylbenzenesulfonamide (CAS 338961-05-0)
- 3-Bromo-1-tosylazepan-4-one (CAS 171009-43-1)
- 4-(3,4-Dichlorophenyl)-N,N-dimethyl-5-(methylsulfonyl)pyrimidin-2-amine (CAS 251307-31-0)
- (4-Bromothiophen-2-yl)(1,5-dioxa-9-azaspiro[5.5]undecan-9-yl)methanone (CAS 1797243-64-1)
- Levetiracetam Impurity 28 (CAS 143164-46-9)
- Cefixime Impurity 43 (CAS CATO-C4X-113943)
- Valproate Impurity 69 (CAS CATO-C4X-116669)
- 3-Aminoquinoxaline-2-carbaldehyde (CAS 67570-54-1)
- 3-(Cinnamylthio)-5-(3,4-dimethoxyphenyl)-4H-1,2,4-triazol-4-amine (CAS 573947-36-1)
- 1-(4-Methylpyrrolo[1,2-d][1,2,4]triazin-1-yl)piperidine-3-carboxylic acid (CAS 1707735-56-5)
- CBLC137 (CAS 1197996-80-7)
- 2-Amino-1-((S)-2-((isopropyl(methyl)amino)methyl)pyrrolidin-1-yl)-3-methylbutan-1-one (CAS 1354032-80-6)
- 2,4-Dichloro-5-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (CAS 1116240-03-9)
- C-Peptide 1 (rat) (CAS 41475-27-8)
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