2-(4-Chlorophenoxy)-5-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile CAS 338964-55-9
| CAS No. | 338964-55-9 |
| Molecular Formula | C19H10ClF3N2O |
| Molecular Weight | 374.74 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(4-Chlorophenoxy)-5-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (CAS 338964-55-9), molecular formula C19H10ClF3N2O and molecular weight 374.74 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(4-Chlorophenoxy)-5-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (C19H10ClF3N2O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H10ClF3N2O |
| Molecular Weight | 374.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorophenoxy Standards
- 2-(2-Chlorophenoxy)-5-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (CAS 338964-53-7)
- 2-(3-Chlorophenoxy)-6-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (CAS 303152-82-1)
- 2-(4-Chlorophenoxy)-6-phenyl-4-(trifluoromethyl)nicotinonitrile (CAS 338749-45-4)
- 3-(4-(2-Chlorophenoxy)piperidine-1-carboxamido)benzoic acid (CAS 1058702-87-6)
- 5-(3-Chlorophenoxy)-1,3-diphenyl-1H-pyrazole-4-carbaldehyde (CAS 956368-13-1)
- 2-((5-((4-Chlorophenoxy)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 332911-17-8)
- 2-(4-Chlorophenoxy)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide (CAS 330201-57-5)
- 2-(4-Chlorophenoxy)-2-((5-chloropyrimidin-2-yl)oxy)-1-phenylethanone (CAS 88350-63-4)
Recommended Standards
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(3,5-dimethoxyphenyl)acetamide (CAS 477890-09-8)
- 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-2-(3,4-dimethoxyphenyl)acetamide (CAS 338407-50-4)
- 2-chloro-N-(2,3-dimethoxybenzyl)-4-(trifluoromethyl)nicotinamide (CAS 680213-87-0)
- 4-[(4-Chlorophenyl)methyl]-2-(2,6-difluorophenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile (CAS 672951-30-3)
- 2-(2,4-Dimethylphenyl)-1H-indole-3-carbaldehyde (CAS 590390-99-1)
- 1,3,2-Dioxaborolane, 2,2′-(2,5-selenophenediyl)bis[4,4,5,5-tetramethyl- (CAS 1611991-43-5)
- Ethyl 7-methyl-2-oxo-1,2-dihydropyrazolo[1,5-a]pyridine-6-carboxylate (CAS 937602-26-1)
- 2-(4-Methylthiazol-5-yl)acetaldehyde (CAS 18764-34-6)
- (2-Cyclohexen-1-ylmethyl)amine (CAS 58714-95-7)
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carbonitrile (CAS 1642844-61-8)
- 6-(Methylsulfonyl)-1-(oxiran-2-ylmethoxy)-1H-indole (CAS 849924-91-0)
- 5-Fluoro-1,3-dimethyl-4-nitro-1h-pyrazole (CAS 1392274-44-0)
- 2-bromo-5-(1,2-oxazol-3-yl)-1,3,4-thiadiazole (CAS 1342234-81-4)
- Semaglutide Impurity 167 (CAS CATO-C4X-2226167)
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