1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(6-chloropyridin-2-yl)piperazine CAS 338979-26-3
| CAS No. | 338979-26-3 |
| Molecular Formula | C15H13Cl2F3N4 |
| Molecular Weight | 377.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(6-chloropyridin-2-yl)piperazine (CAS 338979-26-3) is a high-purity analytical reference standard with the molecular formula C15H13Cl2F3N4 and a molecular weight of 377.19 g/mol.
The molecular framework of 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(6-chloropyridin-2-yl)piperazine (C15H13Cl2F3N4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C15H13Cl2F3N4 |
| Molecular Weight | 377.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
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Recommended Standards
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- Methyl 2-(3-bromo-4-hydroxy-5-methoxyphenyl)-1H-benzo[d]imidazole-6-carboxylate (CAS 1416343-22-0)
- 1,4,5,8-Tetraamino-2-bromo-7-methoxyanthracene-9,10-dione (CAS 88603-38-7)
- 6-(propan-2-yloxy)pyridine-3-carboximidamide dihydrochloride (CAS 1394686-55-5)
- N-Methyl-1-(4-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)methanamine (CAS 884507-32-8)
- 5-bromo-2-methyl-1-(propan-2-yl)-1H-1,3-benzodiazole (CAS 1368559-67-4)
- 2-(Aminomethyl)-5-fluorophenol (CAS 870669-90-2)
- diphenyltolylphosphine (CAS 1031-93-2)
- 6-Bromopyrazine-2-carboxamide (CAS 1209459-76-6)
- Ramosetron impurity 32 (CAS 167545-91-7)
- (4R,5R)-Methyl 3-methyl-5-phenyl-4,5-dihydroisoxazole-4-carboxylate (CAS 244611-29-8)
- 2,5-Dibromo-isonicotinicacid (CAS 942473-59-8)
- semaglutide (CAS 782487-28-9)
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