6-Chloro-3-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-8-fluoroquinolin-4(1H)-one CAS 677749-53-0
| CAS No. | 677749-53-0 |
| Molecular Formula | C15H6Cl2F4N2O |
| Molecular Weight | 377.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 6-Chloro-3-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-8-fluoroquinolin-4(1H)-one (C15H6Cl2F4N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies 6-Chloro-3-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-8-fluoroquinolin-4(1H)-one (CAS 677749-53-0), a certified reference material (molecular formula C15H6Cl2F4N2O, MW 377.12 g/mol) for analytical method development and quality control.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 6-Chloro-3-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-8-fluoroquinolin-4(1H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H6Cl2F4N2O |
| Molecular Weight | 377.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)difluoromethyl)thiazole-4-carbonyl chloride (CAS 1823183-05-6)
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- 8-Chloro-4-((3-chloro-4-fluorophenyl)amino)-6-nitroquinoline-3-carbonitrile (CAS 915369-47-0)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(6-chloropyridin-2-yl)piperazine (CAS 338979-26-3)
- N-(2-chloro-5-(trifluoromethyl)phenyl)-2-((4-chlorobenzyl)amino)acetamide (CAS 297150-43-7)
- 4-(2-Chloro-5-fluoropyrimidin-4-ylamino)-N-(2-chlorophenyl)benzamide (CAS 1158838-41-5)
- 1,2-Bis(2-chloro-5-nitrophenyl)disulfane (CAS 20201-05-2)
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Recommended Standards
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- 5-Nitro-2,3-dihydro-1H-inden-2-amine (CAS 212845-77-7)
- 1-(5-Methylthiophen-2-yl)propan-1-ol (CAS 132706-15-1)
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