2-{[(2-chlorophenyl)methyl]sulfanyl}-4-[(4-chlorophenyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline CAS 339019-41-9
| CAS No. | 339019-41-9 |
| Molecular Formula | C21H18Cl2N2S2 |
| Molecular Weight | 433.42 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-{[(2-chlorophenyl)methyl]sulfanyl}-4-[(4-chlorophenyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline (CAS 339019-41-9), molecular formula C21H18Cl2N2S2 and molecular weight 433.42 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-{[(2-chlorophenyl)methyl]sulfanyl}-4-[(4-chlorophenyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline (C21H18Cl2N2S2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-{[(2-chlorophenyl)methyl]sulfanyl}-4-[(4-chlorophenyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H18Cl2N2S2 |
| Molecular Weight | 433.42 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related chlorophenyl Standards
- 2-{[(4-chlorophenyl)methyl]sulfanyl}-4-[(4-chlorophenyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline (CAS 339019-14-6)
- (E)-[(4-Chlorophenyl)methoxy]({4-[(4-chlorophenyl)sulfanyl]-3-nitrophenyl}methylidene)amine (CAS 338396-08-0)
- 4-[(1E)-3-(4-Chlorophenyl)-3-oxoprop-1-en-1-yl]phenyl 4-chlorobenzene-1-sulfonate (CAS 331460-95-8)
- {5-[(4-chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl}methyl 2,2-dichloroacetate (CAS 318239-60-0)
- 4-Chlorophenyl 4-((3,4-dichloro-1-methyl-1H-pyrazol-5-yl)oxy)benzenesulfonate (CAS 303996-51-2)
- 5-(4-Chlorophenyl)-N-(2,5-dimethoxyphenyl)-1-phenyl-1H-pyrazole-3-carboxamide (CAS 477712-41-7)
- (4-((4-Chlorophenyl)sulfonyl)quinolin-3-yl)(thiomorpholino)methanone (CAS 1111014-26-6)
- 3-(4-((2-Chlorophenyl)sulfonyl)piperazin-1-yl)-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine (CAS 1013835-29-4)
Recommended Standards
- 5-Methyl-12-oxo-N-[4-(trifluoromethoxy)phenyl]-5H,5aH,6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide (CAS 1775503-17-7)
- 5-Ethyl-11-oxo-N-[4-(trifluoromethoxy)phenyl]-5H,5aH,6H,7H,8H,9H,11H-pyrido[2,1-b]quinazoline-3-carboxamide (CAS 1574560-89-6)
- 3,3'-(Isoindoline-1,3-diylidene)bis(quinoline-2,4(1H,3H)-dione) (CAS 85223-06-9)
- Ly 222306 (CAS 154446-98-7)
- Bis(1-adamantyl)-2-dimethylaminophenylphosphine (CAS 1219080-77-9)
- 5-(5,5-Dimethyl-1,3-dioxan-2-yl)-4-ethylvalerophenone (CAS 898755-39-0)
- tert-Butyl 4-{4-[5-(2,4-dichlorophenyl)-1,2,4-oxadiazol-3-yl]phenyl}piperazine-1-carboxylate (CAS 1272756-35-0)
- n-Hexyltrioxyethylene (CAS 25961-89-1)
- 2,6-Bis(chloromethyl)-4-tolylacetate (CAS 19228-70-7)
- Tert-butyl (2-amino-5-methylphenyl)carbamate (CAS 885270-77-9)
- 5-Ethyl-N-(4-fluorophenyl)-11-oxo-5H,5aH,6H,7H,8H,9H,11H-pyrido[2,1-b]quinazoline-3-carboxamide (CAS 1574619-29-6)
- 2-Azaspiro[4.5]Decan-8-one hydrochloride (CAS 2007910-03-2)
- (E)-3-Dimethylamino-1-[3-(6-dimethylamino-4-trifluoromethyl-pyridin-2-yl)-phenyl]-propenone (CAS 1311284-04-4)
- Cholecystokinin Octapeptide (1-3) (desulfated) H-Asp-Tyr-Met-OH (CAS 121880-94-2)
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