Ethyl 2-(methylthio)-4-((4-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxylate CAS 339019-43-1
| CAS No. | 339019-43-1 |
| Molecular Formula | C15H14F3N3O2S |
| Molecular Weight | 357.35 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ethyl 2-(methylthio)-4-((4-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxylate.
Ethyl 2-(methylthio)-4-((4-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxylate (CAS 339019-43-1), molecular formula C15H14F3N3O2S and molecular weight 357.35 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution, Ethyl 2-(methylthio)-4-((4-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxylate is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 357.35 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Ethyl 2-(methylthio)-4-((4-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H14F3N3O2S |
| Molecular Weight | 357.35 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Ethyl Standards
- Ethyl 2-(methylthio)-4-((3-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxylate (CAS 3859-55-0)
- N-(2-(Methylthio)benzo[d]thiazol-6-yl)benzo[d]thiazole-6-carboxamide (CAS 681167-06-6)
- N-(6-(Methylthio)benzo[d]thiazol-2-yl)benzo[d]thiazole-2-carboxamide (CAS 899982-80-0)
- 2-(4-(4-(Methylthio)benzo[d]thiazol-2-yl)piperazin-1-yl)phenol (CAS 1219907-20-6)
- 2,6-Bis(methylthio)-3,5-diphenyl-4H-thiopyran-4-one (CAS 24097-29-8)
- Bis(methylthio)gliotoxin (FR-49175) (CAS 74149-38-5)
- 4-(4-Methyl-5-(methylthio)-4H-1,2,4-triazol-3-yl)-2-(3-(trifluoromethyl)phenyl)thiazole (CAS 400083-71-8)
- Ethyl 2-(methylthio)-4-(3-(trifluoromethyl)phenoxy)pyrimidine-5-carboxylate (CAS 551920-91-3)
Recommended Standards
- Ethyl 3-methyl-5-(3-(trifluoromethyl)benzamido)thiophene-2-carboxylate (CAS 477567-85-4)
- Ethyl 2-((2-(pyridin-2-yl)-6-(trifluoromethyl)pyrimidin-4-yl)thio)propanoate (CAS 338754-11-3)
- Ethyl 4-((3,5-difluorobenzyl)oxy)-6-methylquinoline-3-carboxylate (CAS 923106-21-2)
- 2,2,2-Trifluoro-1-(4-methylphenyl)ethanone O-Tosyl Oxime (CAS 87736-79-6)
- 3-Bromo-5H,6H,7H,8H-imidazo[1,2-a]pyrazine dihydrochloride (CAS 1057338-30-3)
- Ethyl 1-oxo-1H-isochromene-3-carboxylate (CAS 111686-63-6)
- rel-(4aR,7aR)-6-(tert-Butoxycarbonyl)octahydropyrano[2,3-c]pyrrole-7a-carboxylic acid (CAS 2696257-76-6)
- D-(-)-2-Phenylglycine D5 (CAS 1246817-98-0)
- n-(3-Chlorophenyl)-1,4-diazepane-1-carboxamide hydrochloride (CAS 1235440-74-0)
- 2-Pyridin-4-yl-phenylamine (CAS 106047-18-1)
- (1-Methyl-3-phenyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazol-4-yl)methyl 3,5-bis(trifluoromethyl)benzoate (CAS 318289-48-4)
- 1-(4-Chloro-3-fluorophenyl)butan-2-one (CAS 1443339-22-7)
- Benzene, (1-methylethenyl)-, polymer with cyclopentene ann 1,3-pentadiene (CAS 58901-68-1)
- Hexapeptide-1 (CAS CATO-CPTD788821)
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