4-{[(4-chlorophenyl)amino]methylidene}-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one CAS 339020-99-4
| CAS No. | 339020-99-4 |
| Molecular Formula | C11H7ClF3N3O |
| Molecular Weight | 289.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-{[(4-chlorophenyl)amino]methylidene}-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-{[(4-chlorophenyl)amino]methylidene}-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one (CAS 339020-99-4) is a high-purity analytical reference standard with the molecular formula C11H7ClF3N3O and a molecular weight of 289.64 g/mol.
The molecular framework of 4-{[(4-chlorophenyl)amino]methylidene}-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one (C11H7ClF3N3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-{[(4-chlorophenyl)amino]methylidene}-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H7ClF3N3O |
| Molecular Weight | 289.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related chlorophenyl Standards
- 4-{[(2-chlorophenyl)amino]methylidene}-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one (CAS 339020-97-2)
- 4-{[(3-chlorophenyl)amino]methylidene}-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one (CAS 339020-98-3)
- 5-(4-Chlorophenyl)-2-(trifluoromethyl)furan-3-carboxamide (CAS 2197053-72-6)
- N-(4-Chlorophenyl)-6-(Trifluoromethyl)-1,3,5-Triazine-2,4-Diamine (CAS 53387-70-5)
- 2-(3-Chlorophenyl)-6-nitro-1H-benzo[d]imidazol-1-ol (CAS 303148-97-2)
- 6-(4-Chlorophenyl)-4-oxo-4,5-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-3-carboxamide (CAS 1351828-67-5)
- 5-(4-Chlorophenyl)-N-(1H-1,2,4-triazol-5-yl)oxazole-2-carboxamide (CAS 1795413-01-2)
- 1-(3-Chlorophenyl)-n-(diethoxyphosphorylmethyl)methanimine (CAS 1132709-92-2)
Recommended Standards
- 4-Amino-5-chloro-2-(4-(trifluoromethyl)phenyl)pyridazin-3(2H)-one (CAS 923027-45-6)
- 3-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenol (CAS 95711-07-2)
- 5-Amino-4-chloro-2-(4-(trifluoromethyl)phenyl)pyridazin-3(2H)-one (CAS 24181-95-1)
- 2-Chloro-3-((2,2,2-trifluoroethyl)amino)naphthalene-1,4-dione (CAS 866008-04-0)
- 2-{[4-(4-methoxyphenyl)-5-methyl-4h-1,2,4-triazol-3-yl]sulfanyl}acetic acid (CAS 743452-47-3)
- 2-(5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-yl)benzoic acid (CAS 56894-53-2)
- Pigment Red 166 (CAS 3905-19-9)
- 4-Fluoro-2,3-dihydrospiro[indene-1,3'-piperidine] hydrochloride (CAS 1414959-17-3)
- Ethyl 5,7-dimethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (CAS 93514-84-2)
- Trimethyl(2-(tributylstannyl)cyclopropyl)silane (CAS 832132-87-3)
- 2-(4-Isopropylphenyl)-1H-indole-3-carbaldehyde (CAS 590390-96-8)
- 2-Fluoro-N-(2-(pyridin-2-yl)ethyl)benzamide (CAS 1182917-35-6)
- 2-(3-Nitrophenyl)furan (CAS 28988-01-4)
- Tirzepatide Impurity 33 (CAS CATO-C4X-324033)
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