N-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-2-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)oxy]acetamide CAS 339096-77-4
| CAS No. | 339096-77-4 |
| Molecular Formula | C18H14ClF3N4O4 |
| Molecular Weight | 442.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), N-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-2-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)oxy]acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
N-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-2-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)oxy]acetamide (CAS 339096-77-4), molecular formula C18H14ClF3N4O4 and molecular weight 442.78 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, N-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-2-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)oxy]acetamide (C18H14ClF3N4O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 442.78 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C18H14ClF3N4O4 |
| Molecular Weight | 442.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related N Standards
- 4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)(methyl)amino)-5-methyl-2-(4-nitrobenzyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (CAS 860786-15-8)
- 5-Chloro-N-(2,4-difluorophenyl)-2-oxo-1-(4-(trifluoromethyl)benzyl)-1,2-dihydropyridine-3-carboxamide (CAS 338977-82-5)
- 5-Chloro-N-(2,4-difluorophenyl)-6-oxo-1-(3-(trifluoromethyl)benzyl)-1,6-dihydropyridine-3-carboxamide (CAS 339024-18-9)
- 2-{N-[2-chloro-5-(trifluoromethyl)phenyl]methanesulfonamido}-N-(2,4-difluorophenyl)acetamide (CAS 478067-38-8)
- N'-[3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]-6-(trifluoromethyl)pyridine-3-carbohydrazide (CAS 1092346-16-1)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-phenyl-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine (CAS 339106-67-1)
- N-(2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-2-oxoethoxy)benzamide (CAS 303150-03-0)
- 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-N-(4-methoxyphenyl)-1-methyl-1H-imidazole-5-carboxamide (CAS 339278-15-8)
Recommended Standards
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- 5-((4-Chlorophenyl)sulfonyl)-4-(2,4-dichlorophenyl)-N,N-dimethylpyrimidin-2-amine (CAS 339110-24-6)
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- 2-(Dimethylamino)-5-methyl-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-4(3H)-one (CAS 1707566-64-0)
- Sirtinol (CAS 410536-97-9)
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- 4-(4-Ethoxystyryl)-N,N-diphenylaniline (CAS 92003-03-7)
- (D-His1)-Exenatide trifluoroacetate salt (CAS 1678417-09-8)
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