Dapagliflozin Impurity 148 CAS 342043-51-0
| CAS No. | 342043-51-0 |
| Molecular Formula | C18H18O4 |
| Molecular Weight | 298.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dapagliflozin Impurity 148 is closely related to a flavonoid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Dapagliflozin Impurity 148 (CAS 342043-51-0) is a certified pharmaceutical impurity reference standard with the molecular formula C18H18O4 and a molecular weight of 298.33 g/mol.
Dapagliflozin Impurity 148 (C18H18O4) contains a flavonoid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H18O4 |
| Molecular Weight | 298.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 38 (CAS 2132-59-4)
- Dapagliflozin Impurity 45 (CAS 864070-18-8)
- Dapagliflozin Impurity 164 (CAS CATO-C4X-1138164)
- Dapagliflozin Impurity 89 (CAS 5032-10-0)
- Dapagliflozin dibromide impurity (CAS 1043252-56-7)
- Dapagliflozin Impurity 166 (CAS CATO-C4X-1138166)
- Dapagliflozin impurity 217 (CAS 2133407-74-4)
- Dapagliflozin Impurity 193 (CAS CATO-C4X-1138193)
Recommended Standards
- Erlotinib Impurity 118 (CAS 183322-16-9)
- trans-2-Methyl-3-(5’-carboxy-3’-methyl-2’-pentenyl)-1,4-naphthoquinone (CAS 34185-71-2)
- Posaconazole Impurity 106 (CAS 192448-07-0)
- Tert-butyl 4-(3,4-difluorophenyl)piperazine-1-carboxylate (CAS 951626-88-3)
- Lansoprazole Impurity 38 (CAS CATO-C4X-111338)
- Conivaptan Impurity 1 (CAS 947-84-2)
- Tadalafil Impurity 79 (CAS 38082-70-1)
- (R)-Benzyl isopropyl(pyrrolidin-3-yl)carbamate (CAS 1354011-23-6)
- (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2,6-dimethylphenyl)methanone (CAS 898761-87-0)
- 898766-80-8 5-Cyclobutyl-5-oxopentanoic acid DTXSID00645359 (CAS 898766-80-8)
- N-(2-Methyl-1,3-dioxoisoindolin-4-yl)-5-nitrofuran-2-carboxamide (CAS 683232-12-4)
- Cinacalcet Impurity 101 (CAS CATO-C4X-1059101)
- 8-Bromo-7-methoxyquinoline (CAS 36023-06-0)
- Tirzepatide Impurity 33 (CAS CATO-C4X-324033)
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