Dapagliflozin Impurity 45 CAS 864070-18-8
| CAS No. | 864070-18-8 |
| Molecular Formula | C13H10BrClO |
| Molecular Weight | 297.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Dapagliflozin Impurity 45 (CAS 864070-18-8) is a certified pharmaceutical impurity reference standard with the molecular formula C13H10BrClO and a molecular weight of 297.57 g/mol.
Based on its molecular formula C13H10BrClO, Dapagliflozin Impurity 45 contains a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 297.57 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H10BrClO |
| Molecular Weight | 297.57 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl/Br-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 148 (CAS 342043-51-0)
- Dapagliflozin Impurity 38 (CAS 2132-59-4)
- Dapagliflozin Impurity 164 (CAS CATO-C4X-1138164)
- Dapagliflozin dibromide impurity (CAS 1043252-56-7)
- Dapagliflozin Impurity 89 (CAS 5032-10-0)
- Dapagliflozin Impurity 166 (CAS CATO-C4X-1138166)
- Dapagliflozin impurity 217 (CAS 2133407-74-4)
- Dapagliflozin Impurity 195 (CAS CATO-C4X-1138195)
Recommended Standards
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- 4-Bromo-2-chloro-N-[(pyridin-3-yl)methyl]aniline (CAS 195372-58-8)
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- Tofacitinib Impurity 166 DiHCl (CAS 2106832-55-5)
- 3,5-Difluoro-2-isobutoxybenzaldehyde (CAS 1443349-54-9)
- Ethyl 2-(2-(cyclohexanecarbonyl)hydrazinyl)-2-oxoacetate (CAS 1325307-05-8)
- Cefcapene Impurity 49 (CAS CATO-C4X-182449)
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