Lodoxamide lmpurity 10 CAS 34207-46-0
| CAS No. | 34207-46-0 |
| Molecular Formula | C7H6ClN3 |
| Molecular Weight | 167.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Lodoxamide lmpurity 10 is closely related to a nitrile group, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Lodoxamide lmpurity 10 (CAS 34207-46-0, C7H6ClN3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lodoxamide lmpurity 10 (C7H6ClN3) is characterized by a nitrile group, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lodoxamide lmpurity 10 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6ClN3 |
| Molecular Weight | 167.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Lodoxamide Standards
- Lodoxamide lmpurity 11 (CAS 67451-38-1)
- Lodoxamide lmpurity 12 (CAS 69236-82-4)
- Lodoxamide Impurity 2 (CAS 55441-26-4)
- Lodoxamide lmpurity 9 (CAS 61313-43-7)
- Lodoxamide Impurity 3 (CAS 617-36-7)
- Lodoxamide Impurity 6 (CAS 75235-35-7)
- Lodoxamide impurity 24 (CAS 27697-45-6)
- Lodoxamide Impurity 1 (CAS 66223-75-4)
Recommended Standards
- 8-Chloro-3-methyl-[1,2,4]triazolo[4,3-a]pyridine 929000-42-0 C7H6ClN3 V9223 (CAS 929000-42-0)
- 2-chloro-3-methanesulfonylpropanenitrile (CAS 1854-80-4)
- N-((6-chloropyridin-3-yl)methyl)cyanamide (CAS 491593-46-5)
- 1-cyanopropane-1-sulfonyl chloride (CAS 27869-06-3)
- Pregabalin Impurity 54 (CAS 616-42-2)
- Olaparib Impurity 41 (CAS 763114-25-6)
- Nicorandil Impurity 10 Dinitrate (CAS 1798026-96-6(free base))
- Ethyl (S)-2-amino-3-(4-ethoxyphenyl)propanoate hydrochloride (CAS 847449-20-1)
- 5-(3-Aminophenyl)pyrimidin-2-ol (CAS 1111109-04-6)
- 4-Chloro-5-methoxy-2-methylquinazoline (CAS 1223491-40-4)
- 2-Norbornanethiol Acetate (CAS 90611-37-3)
- Ethyl 1-hydroxy-1H-1,2,3-triazole-4-carboxylate (CAS 137156-41-3)
- Atazanavir Hydrazine Analog TriHCl (CAS 198904-87-9)
- Semaglutide impurity 260 (CAS CATO-C4X-2226260)
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