N-(4-Acetylphenyl)-3-chlorobenzamide CAS 342777-38-2
| CAS No. | 342777-38-2 |
| Molecular Formula | C15H12ClNO2 |
| Molecular Weight | 273.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(4-Acetylphenyl)-3-chlorobenzamide.
N-(4-Acetylphenyl)-3-chlorobenzamide (CAS 342777-38-2), molecular formula C15H12ClNO2 and molecular weight 273.71 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(4-Acetylphenyl)-3-chlorobenzamide (C15H12ClNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(4-Acetylphenyl)-3-chlorobenzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H12ClNO2 |
| Molecular Weight | 273.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related N Standards
- N-(3-Acetylphenyl)-3-chlorobenzamide (CAS 196408-42-1)
- N-(3-acetylphenyl)-2-chlorobenzamide (CAS 84833-19-2)
- N-(3-Acetylphenyl)-4-chlorobenzamide (CAS 223500-13-8)
- n-(4-Acetylphenyl)-2-chlorobenzamide (CAS 84833-22-7)
- n-(4-Acetylphenyl)-4-chlorobenzamide (CAS 72269-23-9)
- N-(3-acetylphenyl)-4,5-dimethylthiophene-3-carboxamide (CAS 895920-82-8)
- N-(3-acetylphenyl)-5-ethylthiophene-3-carboxamide (CAS 895935-82-7)
- N-(4-Acetylphenyl)-4,5-dimethylthiophene-3-carboxamide (CAS 895920-78-2)
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- N-[4-(2-Chloroacetyl)phenyl]benzamide (CAS 853574-47-7)
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- Tribenzylphosphine (CAS 7650-89-7)
- 1-(2-Fluorobenzyl)pyrrolidine (CAS 784181-88-0)
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