N-(2,4-difluorophenyl)-3-((3-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide CAS 344273-05-8
| CAS No. | 344273-05-8 |
| Molecular Formula | C19H12F5NO2S |
| Molecular Weight | 413.36 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(2,4-difluorophenyl)-3-((3-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide.
CATO supplies N-(2,4-difluorophenyl)-3-((3-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide (CAS 344273-05-8), a certified reference material (molecular formula C19H12F5NO2S, MW 413.36 g/mol) for analytical method development and quality control.
The molecular framework of N-(2,4-difluorophenyl)-3-((3-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide (C19H12F5NO2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(2,4-difluorophenyl)-3-((3-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H12F5NO2S |
| Molecular Weight | 413.36 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related N Standards
- N-(2,5-Difluorophenyl)-2-[5-(morpholine-4-sulfonyl)-2-oxo-1,2-dihydropyridin-1-yl]acetamide (CAS 1251573-91-7)
- N-(2,4-Difluorophenyl)-2-[5-(morpholine-4-sulfonyl)-2-oxo-1,2-dihydropyridin-1-yl]acetamide (CAS 1251676-57-9)
- 1-((2,6-Difluorophenyl)sulfonyl)-4-(((4-methoxyphenyl)thio)methyl)piperidine (CAS 1421471-89-7)
- 1-(2,4-Difluorophenyl)-3-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}pyrrolidine-2,5-dione (CAS 329059-09-8)
- N-(2,5-difluorophenyl)-2-(2-oxo-5-(piperidin-1-ylsulfonyl)pyridin-1(2H)-yl)acetamide (CAS 1251608-21-5)
- N-(2,4-difluorophenyl)-1-(5-((4-fluorophenyl)thio)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanimine (CAS 477711-92-5)
- N-(2,4-Difluorophenyl)-1,3-dimethyl-5-[3-(trifluoromethyl)phenoxy]-1H-pyrazole-4-carboxamide (CAS 303997-89-9)
- N-(2,4-Difluorophenyl)-4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]benzamide (CAS 321430-17-5)
Recommended Standards
- 8-Nitronaphthalene-1,3,6-trisulfonic acid (CAS 38267-31-1)
- N-(3,5-bis(trifluoromethyl)phenyl)-2-(thiophene-2-carbonyl)hydrazine-1-carbothioamide (CAS 217816-18-7)
- 8-Nitronaphthalene-1,3,5-trisulfonic acid (CAS 66620-35-7)
- Tert-butyl benzyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)carbamate (CAS 849069-11-0)
- 2-(2-Nitrophenyl)-4-(pyren-1-ylmethylene)oxazol-5(4H)-one (CAS 71977-22-5)
- Acetophenone-α-<SUP>13</SUP>C (CAS 10383-88-7)
- (2-Cyano-5-(piperidin-4-yl)phenyl)boronic acid (CAS 2225169-52-6)
- (2E)-N,N-Diethyl-2-(phenylformamido)-3-[(pyrimidin-2-yl)amino]prop-2-enamide (CAS 339010-32-1)
- Fluoxetine Impurity 43 (CAS CATO-C4X-135243)
- N-Benzhydryl-2-bromopropanamide (CAS 23459-40-7)
- 1-(Furan-2-ylmethyl)-1H-pyrazol-5-amine (CAS 3528-56-1)
- O-Desethylpiperidine Flavoxate Methyl Ester (CAS 90101-87-4)
- 2-(2-Chloro-5-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2121512-77-2)
- Liraglutide (13-21) TFA Salt (CAS CATO-C4X-19928)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com