n-Isobutyl-n-(2,2,2-trifluoroacetyl)glycine CAS 344783-88-6
| CAS No. | 344783-88-6 |
| Molecular Formula | C8H12F3NO3 |
| Molecular Weight | 227.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
n-Isobutyl-n-(2,2,2-trifluoroacetyl)glycine (CAS 344783-88-6), molecular formula C8H12F3NO3 and molecular weight 227.18 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, n-Isobutyl-n-(2,2,2-trifluoroacetyl)glycine is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 227.18 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H12F3NO3 |
| Molecular Weight | 227.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- alpha-(trifluoromethyl)quinoline-3-methanol (CAS 497937-75-4)
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- 8-Methyl-5-(trifluoromethyl)quinolin-2(1H)-one (CAS 2101658-61-9)
- Theophylline Impurity 11 (CAS CATO-C4X-182311)
- Alpha-Chaconine (CAS 20562-03-2)
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- 2-(2-((2-Amino-5-(phenylethynyl)pyrimidin-4-yl)amino)ethoxy)ethanol (CAS 393856-91-2)
- (R)-Benzyl 3-(oxetan-3-ylamino)piperidine-1-carboxylate (CAS 1349700-08-8)
- 3-Chloro-4-(cyclopentyloxy)-5-fluorophenylboronic acid (CAS 2096334-04-0)
- rac-(3R,4S)-1-benzyl-3-(2-fluorophenyl)-4-nitropyrrolidine (CAS 1909293-67-9)
- ethyl 2-(adamantan-2-yl)-3-aminopropanoate hydrochloride (CAS 1803572-05-5)
- Clenbuterol-Hydroxymethyl (CAS 38339-18-3)
- Methyl 4-[(2-chloro-6-fluorophenyl)methoxy]benzoate (CAS 128982-50-3)
- D-Ala21-Tirzepatide (CAS CATO-CPTD788913)
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