8-Methyl-5-(trifluoromethyl)quinolin-2(1H)-one CAS 2101658-61-9
| CAS No. | 2101658-61-9 |
| Molecular Formula | C11H8F3NO |
| Molecular Weight | 227.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
8-Methyl-5-(trifluoromethyl)quinolin-2(1H)-one (C11H8F3NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies 8-Methyl-5-(trifluoromethyl)quinolin-2(1H)-one (CAS 2101658-61-9), a certified reference material (molecular formula C11H8F3NO, MW 227.18 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H8F3NO |
| Molecular Weight | 227.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- 1-Methyl-7-(trifluoromethyl)quinolin-4(1H)-one (CAS 108494-53-7)
- (4-(Trifluoromethyl)quinolin-2-yl)methanol (CAS 1116339-56-0)
- 1-Methyl-8-(trifluoromethyl)quinolin-4(1H)-one (CAS 1209284-64-9)
- 6-Methyl-2-(trifluoromethyl)quinolin-4(1H)-one (CAS 123638-04-0)
- β-(Trifluoromethyl)-4-morpholinepropanoic acid (CAS 1343857-33-9)
- 1-(6-(Trifluoromethyl)-1H-indol-4-yl)ethanone (CAS 1352897-41-6)
- 5'-(Trifluoromethyl)-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2'-one (CAS 1360898-86-7)
- 7'-(Trifluoromethyl)spiro[cyclopropane-1,3'-indolin]-2'-one (CAS 1360931-90-3)
Recommended Standards
- 8-Methoxy-5-(trifluoromethyl)quinoline (CAS 316-75-6)
- alpha-(trifluoromethyl)quinoline-3-methanol (CAS 497937-75-4)
- 8-Methoxy-2-(trifluoromethyl)quinoline (CAS 41958-00-3)
- n-Isobutyl-n-(2,2,2-trifluoroacetyl)glycine (CAS 344783-88-6)
- 6-(4-Chloro-3-fluorophenyl)-2-(pent-2-yn-1-yl)pyridazin-3(2H)-one (CAS 142028-15-7)
- 4-(((4-Carboxybutyl)(2-((4-phenethylbenzyl)oxy)phenethyl)amino)methyl)benzoic acid (CAS 329773-35-5)
- 2-amino-N'-hydroxy-4,5-dimethoxybenzenecarboximidamide (CAS 903147-28-4)
- tert-butyl ((S)-2-(4-((2-methylthiazol-4-yl)methoxy)phenyl)-1-((S)-oxiran-2-yl)ethyl)carbamate (CAS 313680-92-1)
- 4,5-Dibromo-2-chloro-3-(difluoromethyl)pyridine (CAS 1804697-97-9)
- 3-(2-(2-Methoxyacetamido)phenoxy)propanamide (CAS 1241572-83-7)
- (5Z,8Z)-N-Hydroxydodeca-5,8,11-trienamide (CAS 89017-04-9)
- (5-Chloro-2-hydroxyphenyl)(5-(trifluoromethyl)-1H-1,2,3-triazol-4-yl)methanone (CAS 497147-48-5)
- 1,2,3,4-Tetrahydroisoquinolin-4-amine hydrochloride (CAS 486453-50-3)
- Peptide 6A (H-6905.0005) (CAS 73549-32-3)
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