Flunarizine Impurity 16 CAS 345-90-4
| CAS No. | 345-90-4 |
| Molecular Formula | C13H9BrF2 |
| Molecular Weight | 283.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 283.11 g/mol gives Flunarizine Impurity 16 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Flunarizine Impurity 16 (CAS 345-90-4, C13H9BrF2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C13H9BrF2, Flunarizine Impurity 16 contains fluorine/bromine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 283.11 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H9BrF2 |
| Molecular Weight | 283.11 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Br-containing |
Related Flunarizine Standards
- Flunarizine EP Impurity A (CAS 27649-60-9)
- Flunarizine EP Impurity A (CAS 27469-60-9)
- Flunarizine Impurity 21 (CAS 39918-90-6)
- Flunarizine impurity 49 (CAS 2922257-65-4)
- Flunarizine Impurity 22 (CAS CATO-C4X-135722)
- Flunarizine Impurity 15 (CAS 365-20-8)
- Flunarizine Impurity 32 (CAS 141528-78-1)
- Flunarizine impurity 36 (CAS 57070-98-1)
Recommended Standards
- 593255-20-0 2-Iodo-1,5-dimethyl-3-nitrobenzene DTXSID20556039 (CAS 593255-20-0)
- Risedronate EP Impurity C (CAS 105462-25-7)
- 2-chloro-1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilane 5565-32-2 Chlorotris(trimethylsilyl)silane (CAS 5565-32-2)
- Risedronate EP Impurity B (CAS 105462-23-5)
- Isavuconazole Impurity 198 (CAS CATO-C4X-1236198)
- Oseltamivir Impurity 87 HCI (CAS CATO-C4X-172087)
- Sildenafil Impurity 303 (CAS CATO-C4X-1128303)
- 2-Ethyl-N-methyl-N-(m-tolyl)butanamide (CAS 406488-30-0)
- 2-((2-Amino-9-propyl-9H-purin-6-yl)thio)acetic acid (CAS 42204-31-9)
- Cp-154526 (CAS 157286-86-7)
- Butein Tetramethyl Ether (CAS 155048-06-9)
- 5-(4-Bromophenyl)-6H-1,3,4-thiadiazin-2-amine (CAS 55185-78-9)
- Scopolamine Hydrobromide Trihydrate (CAS 6533-68-2)
- Tau Peptide (274-288) trifluoroacetate salt (CAS 330456-39-8)
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