1-Bromo-2-chloro-4-(difluoromethoxy)benzene CAS 345226-22-4
| CAS No. | 345226-22-4 |
| Molecular Formula | C7H4BrClF2O |
| Molecular Weight | 257.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Structurally, 1-Bromo-2-chloro-4-(difluoromethoxy)benzene (C7H4BrClF2O) contains a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 257.46 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 1-Bromo-2-chloro-4-(difluoromethoxy)benzene (CAS 345226-22-4), a certified reference material (molecular formula C7H4BrClF2O, MW 257.46 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4BrClF2O |
| Molecular Weight | 257.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl/Br-containing |
Related Bromo Standards
- 2-Bromo-1-chloro-4-(difluoromethoxy)benzene (CAS 1000574-90-2)
- 4-Bromo-1-chloro-2-(difluoromethoxy)benzene (CAS 1000575-20-1)
- 1-Bromo-3-chloro-5-(difluoromethoxy)benzene (CAS 1004112-67-7)
- 1-Bromo-4-chloro-2-(difluoromethoxy)benzene (CAS 1056942-37-0)
- 4-Bromo-2-chloro-1-(difluoromethoxy)benzene (CAS 1062614-42-9)
- 1-Bromo-2-[chloro(difluoro)methoxy]benzene (CAS 112556-12-4)
- 1-Bromo-4-(chlorodifluoromethoxy)benzene (CAS 112556-13-5)
- 2-Bromo-4-chloro-1-(difluoromethoxy)benzene (CAS 1214348-81-8)
Recommended Standards
- (S)-4-Bromo-5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazole (CAS 2641062-81-7)
- 1-Propanamine, 3-(isotridecyloxy)- (CAS 50977-10-1)
- (R)-4-Bromo-5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazole (CAS 2641062-80-6)
- 2,2,2-Trichloro-1-(4-nitro-1h-pyrrol-2-yl)ethan-1-one (CAS 53391-50-7)
- 3-Fluoro-2-(methoxymethyl)aniline (CAS 1340443-15-3)
- [1,2,5]Oxadiazolo[3,4-d]pyrimidine (CAS 14183-23-4)
- 6-Chloro-5-(difluoromethyl)-4-fluoronicotinonitrile (CAS 1805963-46-5)
- (E)-3-(4-Hydroxystyryl)phenol (CAS 63877-76-9)
- 3505-67-7 AR-1J0014 ethyl prop-2-enoate; 2-methylenehexanoic acid; methyl 2-methylprop-2-enoate; styrene (CAS 3505-67-7)
- N-BIs-boc-4-iodo-2-fluoroaniline (CAS 1314985-54-0)
- 5-Methylpyrazolo[1,5-a]pyrimidin-7-ol (CAS 16082-26-1)
- 7-Methyl-7-azaspiro[3.5]Nonane-2-carboxylic acid hydrochloride (CAS 2306272-85-3)
- 8-Methoxyquinoline-2-carbonitrile (CAS 92735-81-4)
- Semaglutide impurity 272 (CAS CATO-C4X-2226272)
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