2-Bromo-4-fluoro-5-nitroaniline CAS 346433-97-4
| CAS No. | 346433-97-4 |
| Molecular Formula | C6H4BrFN2O2 |
| Molecular Weight | 235.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2-Bromo-4-fluoro-5-nitroaniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies 2-Bromo-4-fluoro-5-nitroaniline (CAS 346433-97-4), a certified reference material (molecular formula C6H4BrFN2O2, MW 235.01 g/mol) for analytical method development and quality control.
The molecular framework of 2-Bromo-4-fluoro-5-nitroaniline (C6H4BrFN2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C6H4BrFN2O2 |
| Molecular Weight | 235.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
- 2-Bromo-4-fluoro-6-nitroaniline (CAS 10472-88-5)
- 3-Bromo-6-fluoro-2-nitroaniline (CAS 1119454-21-5)
- 5-Bromo-3-fluoro-2-nitroaniline (CAS 1193385-18-0)
- 2-Bromo-3-fluoro-6-nitroaniline, 97% (CAS 1218764-80-7)
- 3-Bromo-4-fluoro-2-hydroxybenzoic acid (CAS 1257535-20-8)
- 3-Bromo-6-fluoro-2-methyl-5-nitropyridine (CAS 1263282-57-0)
- 2-Bromo-3-fluoro-5-nitroaniline (CAS 1309832-49-2)
- 3-Bromo-2-fluoro-5-nitroaniline (CAS 1309833-32-6)
Recommended Standards
- 2-Bromo-4-fluoro-5-hydroxybenzoic acid (CAS 91659-19-7)
- 2-Bromo-5-fluoro-3,4-dihydroxybenzaldehyde (CAS 2667597-71-7)
- 4-Bromo-2-(fluoromethyl)-5-nitropyridine (CAS 1807232-55-8)
- 2-Bromo-5-fluoro-4-methyl-3-nitropyridine (CAS 917918-84-4)
- n-(3-Fluorophenyl)-1-methylpiperidin-4-amine (CAS 36796-55-1)
- GNE-272, >98% (HPLC) (CAS 1936428-93-1)
- O-Chlorobenzylidene malononitrile (CAS 2698-41-1)
- Lornoxicam impurity 64 (CAS CATO-C4X-201664)
- Fibronectin-Binding Protein (CAS 119977-20-7)
- 1-[(4-isopropylphenyl)sulfonyl]piperidine-4-carboxylic acid (CAS 727983-30-4)
- Caloxin 2A1 trifluoroacetate salt (CAS 350670-85-8)
- 2H-1-Benzopyran-2-one, 6-[(1R,2S)-2,3-dihydroxy-1-methoxy-3-methylbutyl]-7-methoxy- (CAS 425370-70-3)
- 1-((1H-Indol-3-yl)oxy)propan-2-amine (CAS 786580-14-1)
- Semaglutide Impurity 122 (CAS CATO-C4X-2226122)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com