N-(3-Aminophenyl)-2-chloro-4,5-difluorobenzamide CAS 346640-72-0
| CAS No. | 346640-72-0 |
| Molecular Formula | C13H9ClF2N2O |
| Molecular Weight | 282.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(3-Aminophenyl)-2-chloro-4,5-difluorobenzamide.
N-(3-Aminophenyl)-2-chloro-4,5-difluorobenzamide (CAS 346640-72-0), molecular formula C13H9ClF2N2O and molecular weight 282.67 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(3-Aminophenyl)-2-chloro-4,5-difluorobenzamide (C13H9ClF2N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures N-(3-Aminophenyl)-2-chloro-4,5-difluorobenzamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H9ClF2N2O |
| Molecular Weight | 282.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- N-(4-aminophenyl)-2-chloro-4,5-difluorobenzamide (CAS 1087448-65-4)
- 1-(3-Aminophenyl)isoquinoline-4-carbonyl chloride (CAS 90829-25-7)
- n-(3-Aminophenyl)-4-chlorobenzene-1-sulfonamide (CAS 953733-67-0)
- 5-(4-Aminophenyl)-N-(p-tolyl)-1,3,4-thiadiazol-2-amine (CAS 827580-82-5)
- N-[(4-Aminophenyl)sulfonyl]-1-methylcyclopentanecarboxamide (CAS 938421-81-9)
- (4-Aminophenyl)(4-(pyridin-2-yl)piperazin-1-yl)methanone (CAS 885949-69-9)
- 5-(3-Aminophenyl)-1h,2h,3h,4h,7h,8h,9h-pyridazino[4,5-a]pyrrolizine-1,4-dione (CAS 1114822-85-3)
- 5-(4-Aminophenyl)-2,3,8,9-tetrahydro-4H-pyridazino[4,5-a]pyrrolizine-1,4(7H)-dione (CAS 1114823-91-4)
Recommended Standards
- methyl 5-(chlorosulfonyl)-2-fluoro-4-methoxybenzoate (CAS 2060056-99-5)
- 4-Chloro-1-((4-methoxyphenoxy)methyl)-1h-pyrazole-3-carboxylic acid (CAS 1006444-12-7)
- 5-Chloro-2-((2,4-difluorobenzyl)oxy)benzaldehyde (CAS 632625-91-3)
- 5-{[(2-chloropyridin-4-yl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione (CAS 1018812-97-9)
- 2-Acetoxybenzoic-3,4,5,6-d4 Acid (CAS 97781-16-3)
- (S)-2-(((1-Benzylpyrrolidin-2-yl)methyl)(cyclopropyl)amino)ethanol (CAS 1353996-91-4)
- 2-(1-Cyclopentylpiperidin-4-yl)ethanamine (CAS 132740-61-5)
- 4-(6-Methyl-2-benzothiazolyl)phenylisocyanate (CAS 67229-93-0)
- 2,8-Dibromo-3-fluoroquinoline-4-carboxylic acid (CAS 834884-17-2)
- Methyl 2-amino-5-methoxy-3-methylbenzoate (CAS 1007113-24-7)
- N-[3-(sec-Butoxy)phenyl]-N-{2-[2-(sec-butyl)-phenoxy]ethyl}amine (CAS 1040685-63-9)
- Norepinephrine EP Impurity C HCl(Dobutamine EP Impurity A HCl) (CAS 62-31-7;51-61-6(Free Base))
- (R)-3-amino-2-(2-bromobenzyl)propanoic acid (CAS 1260605-64-8)
- Pancreatic Polypeptide (31-36) Free Acid, human (CAS 192432-73-8)
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